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Psoriasis News -- ScienceDaily

Long-term sustained effect of biological psoriasis treatment (Wed, 28 Jun 2017)
Biological treatment of psoriasis shows a good efficacy in clinical trials. Since most analyses have focused on short-term outcomes of single biological agents, little has been known about long-term outcomes in clinical practice, where switching between biological agents is common. A study that followed 583 individuals for up to 10 years shows a satisfactory long-term effectiveness of biologic treatments.
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Study casts doubt about link between eczema, cardiovascular disease (Fri, 16 Jun 2017)
Despite mixed evidence recently about an association between atopic dermatitis and cardiovascular disease, a new study that analyzed more than 250,000 medical records suggests there is no link.
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Promising new treatment option for chronic plaque psoriasis (Tue, 06 Jun 2017)
A new study tested the efficacy of tildrakizumab, an antibody that targets only a very specific immune system pathway. More than 60 percent of all patients who received the active medication showed improvement, compared to less than 10 percent of patients who received placebos.
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Secukinumab and ixekizumab in psoriasis: Considerable added benefit for certain patients (Fri, 02 Jun 2017)
There were notably more remissions with Secukinumab and ixekizumab than under the comparator therapies for psoriasis. In future, the analysis of symptoms should not be limited to improvements at one time point.
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Cancer therapy shows promise for psoriasis treatment (Wed, 31 May 2017)
HDAC inhibitors, already widely used to treat cancer, may be an effective therapy for psoriasis as well, scientists report.
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Handheld scanner reveals vascularization in psoriasis patients (Wed, 31 May 2017)
A newly developed tissue scanner allows looking under the skin of psoriasis patients. This provides clinically relevant information, such as the structure of skin layers and blood vessels, without the need for contrast agents or radiation exposure.
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Drug for refractory psoriatic arthritis shows promise in clinical trial (Wed, 24 May 2017)
Patients with psoriatic arthritis for whom standard-of-care pharmaceutical treatments have provided no lasting relief experienced a significant reduction in symptoms, including joint tenderness and swelling, have reported promising results when they were given a new drug.
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Largest psoriasis meta-analysis to date yields new genetic clues (Wed, 24 May 2017)
The identification of 16 additional genetic markers will help researchers get closer to understanding how -- and why -- psoriasis develops.
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Potential target for treatment of skin inflammation in eczema and psoriasis (Mon, 22 May 2017)
Superficially, psoriasis and atopic dermatitis may appear similar but their commonalities are only skin deep. Atopic dermatitis, also known as eczema, is primarily driven by an allergic reaction, while psoriasis is considered an autoimmune disease. Nevertheless, researchers were able to pinpoint a common driver of skin inflammation in both diseases.
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Cannabinoids may soothe certain skin diseases, say researchers (Tue, 18 Apr 2017)
Cannabinoids contain anti-inflammatory properties that could make them useful in the treatment of a wide-range of skin diseases, according to researchers.
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Severe psoriasis predominantly affects men (Fri, 24 Mar 2017)
The fact that men are overrepresented in psoriasis registers and consume more psoriasis care have long led researchers to believe that the common skin disease disproportionately affects men. A unique study with 5,438 Swedish psoriasis patients now reveals that women have a statistically significant lower incidence of severe psoriasis compared to men.
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Inflammatory disease trigger revealed (Wed, 22 Feb 2017)
Scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. The discovery could lead to new and existing medicines that target the molecule being investigated as a way of treating inflammatory diseases, such as psoriasis and inflammatory bowel disease.
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Depression puts psoriasis patients at significantly greater risk of psoriatic arthritis (Wed, 22 Feb 2017)
Psoriasis is a lifelong disease that is associated with significant cosmetic and physical disability and puts patients at increased risk for many major medical disorders. A multidisciplinary team of researchers has found that psoriasis patients who developed depression were at a 37 percent greater risk of subsequently developing psoriatic arthritis, compared with psoriasis patients who did not develop depression.
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Cytotoxic immune cell in sick and healthy skin a key to understanding vitiligo (Mon, 20 Feb 2017)
With the aid of thousands of skin biopsies and over a hundred kilograms of skin, researchers have observed how two subgroups of immune cell behave in healthy skin. This functional dichotomy is preserved in the inflammatory diseases psoriasis and vitiligo. The study opens the way for more targeted local treatments for patchy inflammatory skin disorders.
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Treatment has no sufficient effect in one of five psoriasis patients (Thu, 02 Feb 2017)
A substantial part of people, one in five, undergoing systemic treatment for psoriasis (i.e. pills taken orally, injections or infusions) still have considerable problems with their disease, according to a recent study.
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Why thick skin develops on our palms and soles, and its links to cancer (Wed, 01 Feb 2017)
Foot callouses/keratoderma (thickened skin) can be linked to cancer of the esophagus (gullet), report researchers.
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Immune system's 'workaround' may explain heart disease in psoriasis patients (Thu, 08 Dec 2016)
Two new studies describe how the inflammatory response to psoriasis can alter levels of several immune system molecules, ultimately increasing a person’s risk of thrombosis, which can include fatal blood clots
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Is an agent used to treat psoriasis aimed at the wrong target? (Wed, 30 Nov 2016)
The antibody ustekinumab is in use for treatment of psoriasis since 2009. It inhibits the underlying inflammation by neutralizing certain messengers of the immune system. Researchers now shows that one of these messengers could actually be helpful in battling the illness.
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New insights into skin cells could explain why our skin doesn't leak (Tue, 29 Nov 2016)
The discovery of the shape and binding capability of epidermal cells could explain how skin maintains a barrier even when it is shedding. New research into how epidermal cells form a barrier may explain the paradox of how we can shed them without compromising our skin's integrity. It could also help us to understand what happens when it forms incorrectly, which could lead to conditions like psoriasis and eczema.
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Fungal skin infections commonly misdiagnosed (Thu, 17 Nov 2016)
Dermatophyte infections, the most common kind of fungal infection in the skin, hair, or nails, affect an estimated 25 percent of the world's population and have accounted for 51 million outpatient visits over the last 10 years in the U.S. Now researchers report that fungal skin infections may be commonly misdiagnosed.
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