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Psoriasis News -- ScienceDaily

Newly identified bacteria-killing protein needs vitamin A to work (Tue, 14 May 2019)
People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. New research sheds some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work.
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Some biologic treatments for psoriasis may be safer for patients (Sat, 11 May 2019)
Dermatologists found a decreased risk of infection in patients with psoriasis using some of the newer, more targeted medications compared to those taking methotrexate, a drug widely used since the 1960s as a first line treatment for moderate-to-severe psoriasis.
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New potential approach to treat atopic dermatitis (Mon, 18 Mar 2019)
Researchers have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease.
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Study links psoriasis treatment and improvement in heart artery disease (Tue, 05 Feb 2019)
Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The findings highlight how immunotherapies that treat inflammatory conditions might play a role in the reduction of cardiovascular disease risks.
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Molecule discovery holds promise for gene therapies for psoriasis (Thu, 20 Dec 2018)
Scientists have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide.
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Link between autoimmune, heart disease explained in mice (Thu, 08 Nov 2018)
Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels.
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Stigmatizing views and myths about psoriasis are pervasive in the United States (Thu, 30 Aug 2018)
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.
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Insight into potential new strategy to target skin diseases like psoriasis (Fri, 04 May 2018)
Research has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation.
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Psoriasis treated with compound derived from immune cells (Wed, 18 Apr 2018)
A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study.
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Drug that treats psoriasis also reduces aortic vascular inflammation (Fri, 16 Feb 2018)
An antibody used to treat the skin disease psoriasis is also effective at reducing aortic inflammation, a key marker of future risk of major cardiovascular events.
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Scientists shed light on a key molecular mechanism of autoimmune and inflammatory diseases (Wed, 17 Jan 2018)
An international team of researchers has unraveled a crucial aspect of the molecular basis of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis and Crohn's disease. Focusing on the immunomodulatory cytokine IL-23 they discovered that its pro-inflammatory activity, which underlies a wide range of inflammatory diseases, critically depends on structural activation of the cytokine by its receptor, IL-23R.
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Preventing psoriasis with vanillia extract (Wed, 29 Nov 2017)
Small amounts of artificial vanilla extract, also known as vanillin, are in a wide range of products, from baked goods to perfumes. But vanillin's versatility doesn't stop there. In a recent mouse study researchers report that this compound could also prevent or reduce psoriatic skin inflammation.
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Psoriasis severity linked to increased risk of type 2 diabetes (Tue, 14 Nov 2017)
People with psoriasis are at a higher risk to develop type 2 diabetes than those without psoriasis, and the risk increases dramatically based on the severity of the disease. Researchers found people with psoriasis that covers 10 percent of their body or more are 64 percent more likely to develop diabetes than those without psoriasis, independent of traditional risk factors such as body weight.
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How the skin becomes inflamed: Toxin-producing bacteria (Wed, 08 Nov 2017)
Researchers report the discovery of a key underlying immune mechanism that explains why to how our skin becomes inflamed from conditions such as atopic dermatitis, more commonly known as eczema. Toxin-producing bacteria on the surface of our skin induces a protein that causes our own cells to react and cause inflammation.
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Inflammation trains the skin to heal faster (Wed, 18 Oct 2017)
Stem cells in the skin remember an injury, helping them close recurring wounds faster, researchers have found. The discovery could advance research and treatment of psoriasis and other inflammatory diseases.
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Uncovering why psoriasis recurs (Thu, 28 Sep 2017)
New research helps address a longstanding question about the inflammatory skin condition psoriasis: Why do skin lesions that have resolved with therapy recur in the same locations after a patient stops using topical steroids?
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Fire ant venom compounds may lead to skin treatments (Mon, 11 Sep 2017)
Solenopsins, the main toxic components of fire ant venom, chemically resemble ceramides, which are lipid-like molecules essential for maintaining for the barrier function of the skin. Solenopsin analogs can reduce skin thickening and inflammation in a mouse model of psoriasis, scientists have shown.
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Severity of psoriasis linked to increased risk of early death (Tue, 29 Aug 2017)
The more the surface area of the body is covered by psoriasis, the greater the risk of death for the patient suffering from the condition, according to a new analysis. Patients with psoriasis on 10 percent or more of their body are at almost double the risk of death.
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Long-term sustained effect of biological psoriasis treatment (Wed, 28 Jun 2017)
Biological treatment of psoriasis shows a good efficacy in clinical trials. Since most analyses have focused on short-term outcomes of single biological agents, little has been known about long-term outcomes in clinical practice, where switching between biological agents is common. A study that followed 583 individuals for up to 10 years shows a satisfactory long-term effectiveness of biologic treatments.
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Study casts doubt about link between eczema, cardiovascular disease (Fri, 16 Jun 2017)
Despite mixed evidence recently about an association between atopic dermatitis and cardiovascular disease, a new study that analyzed more than 250,000 medical records suggests there is no link.
>> Read More

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