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Getting under the skin of psoriasis (Wed, 22 Jul 2020)
Psoriasis afflicts millions of people worldwide, but treatments are limited to small molecules like steroids, which can cause skin thinning and lose their effectiveness over time. Medical researchers have circumvented those problems by using a topical ionic liquid to effectively deliver an RNA-based therapy directly into the skin of mice with psoriasis, which reduced multiple psoriasis-related gene products as well as redness and inflammation, resolving the longstanding challenge of delivering nucleic acids into cells.
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Western diet rich in fat and sugar linked to skin inflammation (Tue, 18 Feb 2020)
Dietary components, rather than obesity itself, may lead to skin inflammation and the development of psoriasis, a study has found.
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Increased depression, suicidal thoughts and stress are reported in patients with chronically itchy skin (Wed, 30 Oct 2019)
Itch is a very common symptom in patients suffering from skin diseases. In a new study on the psychological burden of itch, investigators report that the presence of itch in dermatological patients was significantly associated with clinical depression, suicidal ideation and stress. They recommend providing patients with access to a multidisciplinary team to prevent and manage problems associated with itch.
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How do ketogenic diets affect skin inflammation? (Thu, 17 Oct 2019)
Not all fats are equal in how they affect our skin, according to a new study. The investigators found that different ketogenic diets impacted skin inflammation differently in psoriasiform-like skin inflammation in mice. Ketogenic diets heavy in medium-chain triglycerides (MCTs) such as coconut, especially in combination with omega-3 fatty acids from fish oil and plant sources like nuts and seeds, exacerbated psoriasis.
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Psoriasis drug target offers potential for osteosarcoma (Wed, 18 Sep 2019)
A treatment for psoriasis could be repurposed to treat a rare but aggressive form of youth cancer, new findings suggest.
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New ways of developing treatment of chronic inflammation (Fri, 30 Aug 2019)
Researchers have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV. A group of transmitter substances (cytokines) in the immune system, the so-called IL-1 family, has been shown to play an important role in many of these diseases by regulating the body's immune responses.
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Psoriasis therapy linked to reduced coronary inflammation in patients with skin condition (Wed, 31 Jul 2019)
Researchers have found that anti-inflammatory biologic therapies used to treat moderate to severe psoriasis can significantly reduce coronary inflammation in patients with the chronic skin condition. Scientists said the findings are particularly notable because of the use of a novel imaging biomarker, the perivascular fat attenuation index (FAI), that was able to measure the effect of the therapy in reducing the inflammation.
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Vaccinations not a risk factor for multiple sclerosis (Wed, 31 Jul 2019)
Data from over 12,000 multiple sclerosis (MS) patients formed the basis of a new study which investigated the population's vaccination behavior in relation to MS. It showed that five years before their diagnosis, MS patients were statistically less likely to receive vaccinations than comparator groups. Consequently, there was no positive correlation between vaccinations and the development of MS.
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Psoriasis patients turn to alternative medicine when traditional treatments fail (Thu, 20 Jun 2019)
A recent survey from the GW School of Medicine and Health Sciences found patients with psoriasis frequently use complementary or alternative therapies to treat their symptoms when traditional treatments fail.
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Newly identified bacteria-killing protein needs vitamin A to work (Tue, 14 May 2019)
People who have inadequate vitamin A in their diets are more susceptible to skin infection, yet how that vitamin affects skin immunity has been unclear. New research sheds some light on that mystery by identifying a previously unknown bacteria-killing protein on the epidermis that requires the vitamin to work.
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Some biologic treatments for psoriasis may be safer for patients (Sat, 11 May 2019)
Dermatologists found a decreased risk of infection in patients with psoriasis using some of the newer, more targeted medications compared to those taking methotrexate, a drug widely used since the 1960s as a first line treatment for moderate-to-severe psoriasis.
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New potential approach to treat atopic dermatitis (Mon, 18 Mar 2019)
Researchers have demonstrated that the same immune cells that protect us against skin fungi also encourage the inflammatory symptoms of atopic dermatitis. An antibody therapy could alleviate this chronic inflammatory skin disease.
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Study links psoriasis treatment and improvement in heart artery disease (Tue, 05 Feb 2019)
Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The findings highlight how immunotherapies that treat inflammatory conditions might play a role in the reduction of cardiovascular disease risks.
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Molecule discovery holds promise for gene therapies for psoriasis (Thu, 20 Dec 2018)
Scientists have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide.
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Link between autoimmune, heart disease explained in mice (Thu, 08 Nov 2018)
Autoimmune diseases such as psoriasis, lupus and rheumatoid arthritis more than double the risk of cardiovascular disease. A new study shows that immune cells that arise during autoimmune disease cause cholesterol to become trapped inside blood vessels.
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Stigmatizing views and myths about psoriasis are pervasive in the United States (Thu, 30 Aug 2018)
The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease. New multidisciplinary research involving both psychologists and dermatologists is the first to examine how common this stigma may be among the general population of the United States as well as among medical students.
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Insight into potential new strategy to target skin diseases like psoriasis (Fri, 04 May 2018)
Research has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation.
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Psoriasis treated with compound derived from immune cells (Wed, 18 Apr 2018)
A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study.
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Drug that treats psoriasis also reduces aortic vascular inflammation (Fri, 16 Feb 2018)
An antibody used to treat the skin disease psoriasis is also effective at reducing aortic inflammation, a key marker of future risk of major cardiovascular events.
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Scientists shed light on a key molecular mechanism of autoimmune and inflammatory diseases (Wed, 17 Jan 2018)
An international team of researchers has unraveled a crucial aspect of the molecular basis of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis and Crohn's disease. Focusing on the immunomodulatory cytokine IL-23 they discovered that its pro-inflammatory activity, which underlies a wide range of inflammatory diseases, critically depends on structural activation of the cytokine by its receptor, IL-23R.
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