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MedWorm: Psoriasis

Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease (Tue, 07 Jul 2015)
The epidermis is the outermost skin layer and provides the first line of defence against the external environment. Keratinocytes are the most predominant cells in the epidermis and play a critical role in maintaining epidermal barrier function. When the barrier is disrupted any of a number of diseases, such as chronic wounds, psoriasis, pemphigus, atopic dermatitis or toxic epidermal necrolysis, can take hold. Activated protein C (APC) or its precursor, protein C, is abundantly expressed by skin epidermal keratinocytes and stimulates their proliferation and migration, and inhibits apoptosis and inflammation, leading to a healing phenotype. Importantly, APC also increases the barrier function of keratinocytes by promoting expression and cell-cell contact redistribution of tight junction pro... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Lack of preclinical support for the efficacy of HDAC inhibitors in the treatment of psoriasis (Mon, 06 Jul 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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Demographics and disease characteristics of patients with psoriasis enrolled in the British Association of Dermatologists Biologic Interventions Register (Mon, 06 Jul 2015)
ConclusionsBADBIR is an invaluable resource to study the safety and effectiveness of both biologic and conventional systemic therapies. Understanding differences in baseline characteristics between cohorts is crucial in undertaking future pharmacovigilance studies. (Source: British Journal of Dermatology)
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In silico database screening of potential targets and pathways of compounds contained in plants used for psoriasis vulgaris (Sat, 04 Jul 2015)
Abstract Reviews and meta-analyses of clinical trials identified plants used as traditional medicines (TMs) that show promise for psoriasis. These include Rehmannia glutinosa, Camptotheca acuminata, Indigo naturalis and Salvia miltiorrhiza. Compounds contained in these TMs have shown activities of relevance to psoriasis in experimental models. To further investigate the likely mechanisms of action of the multiple compounds in these TMs, we undertook a computer-based in silico investigation of the proteins known to be regulated by these compounds and their associated biological pathways. The proteins reportedly regulated by compounds in these four TMs were identified using the HIT (Herbal Ingredients' Targets) database. The resultant data were entered into the PANTHER (Protein AN...
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Metabolic syndrome in psoriasis patients. Residual inflammation and pro‐inflammatory IL17 signaling reduce length of remission. A follow‐up study (Sat, 04 Jul 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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A tale of two sisters: identical IL36RN mutations and discordant phenotypes (Sat, 04 Jul 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation (Sat, 04 Jul 2015)
Publication date: Available online 3 July 2015 Source:Pharmacological Research Author(s): Ahmed Nadeem , Naif O. Al-Harbi , Mohamed M. Al-Harbi , Ahmed M. El-Sherbeeny , Sheikh F. Ahmad , Nahid Siddiqui , Mushtaq A. Ansari , Khairy M.A. Zoheir , Sabry M. Attia , Khaled A. Al-Hosaini , Shakir D. Al-Sharary Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of psoriasis. The small molecule bromodomain and extraterminal domain (BET) inhibitors, that disrupt interaction of BET proteins with acetylated histones have recently demonstr...
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Exclusive: Hospira wins French biosimilar drug tender at 45 percent discount (Fri, 03 Jul 2015)
PARIS (Reuters) - A major French hospital group has chosen a cheap copycat version of a top-selling drug for treating its patients with rheumatoid arthritis, Crohn's disease and psoriasis in a victory for a new type of medicine known as biosimilars.    (Source: Reuters: Health)
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A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis (Fri, 03 Jul 2015)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
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Skin disorders in elderly subjects (Fri, 03 Jul 2015)
ConclusionsSkin disorders are common in elderly people. Systemic diseases promote the development of dermatological conditions. A comprehensive approach to health problems in elderly subjects requires knowledge of dermatology. (Source: International Journal of Dermatology)
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