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MedWorm: Psoriasis

Cyclosporine is Superior to Tacrolimus in Liver Transplant Recipients with Recurrent Psoriasis. (Mon, 01 Sep 2014)
Conclusions PS may relapse after LT despite IS, concomitant AID may be the main predisposing factor to disease relapses, and CsA seems to be more potent than TAC for treating rPS in LTR. PMID: 25163829 [PubMed - in process] (Source: Annals of Transplantation) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Patent watch: Stelara safe after IL-12 antibody dispute (Mon, 01 Sep 2014)
Nature Reviews Drug Discovery 13, 647 (2014). doi:10.1038/nrd4423 Author: Charlotte Harrison AbbVie has lost a patent dispute in which it tried to show that Janssen's Stelara (ustekinumab) — an antibody binding to interleukin-12 (IL-12) and IL-23 that is marketed for the treatment of psoriasis and psoriatic arthritis — infringed on two patents describing IL-12-targeting antibodies owned (Source: Nature Reviews Drug Discovery)
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Psoriasis sparing the polio-affected limb: Is it merely the koebner phenomenon? (Mon, 01 Sep 2014)
We report a case of an adult male, who presented with psoriasis distributed all over the body but with almost complete sparing of the polio-affected left lower limb. (Source: Indian Journal of Dermatology)
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Severity of psoriasis among adult males is associated with smoking, not with alcohol use (Mon, 01 Sep 2014)
James KH Ho, John HG AntrumIndian Journal of Dermatology 2014 59(5):516-516 (Source: Indian Journal of Dermatology)
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Addition of cyclosporine to adalimumab improved psoriasis and adalimumab-induced injection site reaction (Mon, 01 Sep 2014)
Satoshi Nakamizo, Yoshiki Miyachi, Kenji KabashimaIndian Journal of Dermatology 2014 59(5):522-523 (Source: Indian Journal of Dermatology)
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Risk of tuberculosis with the use of anti-TNF medications in psoriasis: incidence, screening and management. (Fri, 29 Aug 2014)
Authors: Kasiraman V, Atwan AA, Durojaiye OC, Kalavala M, Piguet V Abstract Tumor necrosis factor (TNF) plays an important role in containing mycobacterial infections. With the rapidly increasing role of TNF inhibitors in dermatology, tuberculosis (TB) is becoming an important and worrisome concern to dermatologists. This paper aims to provide a comprehensive review on the incidence of TB in patients treated with anti-TNF, the variety of TB screening methods, and management of these cases. Various national recommendations have been highlighted. The monoclonal antibodies, infliximab and adalimumab, appear to be more associated with the risk of TB reactivation than the soluble receptor etanercept. Tuberculosis associated with TNF inhibitors, in contrast to classical TB, is more likel... MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Social impact of the burden of psoriasis: effects on patients and practice. (Fri, 29 Aug 2014)
Authors: Feldman SR, Malakouti M, Koo JY Abstract The raised, scaly, and erythematous plaques associated with psoriasis can be cosmetically disfiguring, which may provoke disgust, fear, and aversion in others. Consequently, the social stigma of psoriasis can be devastating for patients, evoking feelings of shame and anxiety about how they are perceived. In recent years, appreciation of psoriasis as a disease that can cause social distress and impairment has increased. This review discusses the manifold social burdens of psoriasis; different and emerging therapies that may mitigate these burdens by improving outcomes associated with the underlying disease; and psoriasis management in the context of healthcare reform changes focused on assessing the quality and value of patient care....
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Prioritizing dermatoses: rationally selecting guideline topics (Fri, 29 Aug 2014)
ConclusionDermatological professional organizations worldwide succeeded in developing guidelines for all top 20 topics. Respondents mostly agree with (inter)national guideline programmes and literature concerning the criteria important to selecting guideline topics. (Source: Journal of the European Academy of Dermatology and Venereology)
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A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue (Fri, 29 Aug 2014)
ConclusionHLA‐B*58 was associated with GT and HLA‐B*57 was possibly associated with psoriasis. This suggested that some GT cases may represent true oral psoriasis and some may represent only GT. Therefore, it is necessary to make this distinction and increase our sample size to improve the correct diagnosis and treatment of these conditions. (Source: Journal of the European Academy of Dermatology and Venereology)
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Influence of TNF‐α gene polymorphisms in coronary artery calcification in psoriasis patients (Fri, 29 Aug 2014)
(Source: Journal of the European Academy of Dermatology and Venereology)
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