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MedWorm: Psoriasis

Risk of tuberculosis with the use of anti-TNF medications in psoriasis: incidence, screening and management. (Fri, 29 Aug 2014)
Authors: Kasiraman V, Atwan AA, Durojaiye OC, Kalavala M, Piguet V Abstract Tumor necrosis factor (TNF) plays an important role in containing mycobacterial infections. With the rapidly increasing role of TNF inhibitors in dermatology, tuberculosis (TB) is becoming an important and worrisome concern to dermatologists. This paper aims to provide a comprehensive review on the incidence of TB in patients treated with anti-TNF, the variety of TB screening methods, and management of these cases. Various national recommendations have been highlighted. The monoclonal antibodies, infliximab and adalimumab, appear to be more associated with the risk of TB reactivation than the soluble receptor etanercept. Tuberculosis associated with TNF inhibitors, in contrast to classical TB, is more likel... MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Social impact of the burden of psoriasis: effects on patients and practice. (Fri, 29 Aug 2014)
Authors: Feldman SR, Malakouti M, Koo JY Abstract The raised, scaly, and erythematous plaques associated with psoriasis can be cosmetically disfiguring, which may provoke disgust, fear, and aversion in others. Consequently, the social stigma of psoriasis can be devastating for patients, evoking feelings of shame and anxiety about how they are perceived. In recent years, appreciation of psoriasis as a disease that can cause social distress and impairment has increased. This review discusses the manifold social burdens of psoriasis; different and emerging therapies that may mitigate these burdens by improving outcomes associated with the underlying disease; and psoriasis management in the context of healthcare reform changes focused on assessing the quality and value of patient care....
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Prioritizing dermatoses: rationally selecting guideline topics (Fri, 29 Aug 2014)
ConclusionDermatological professional organizations worldwide succeeded in developing guidelines for all top 20 topics. Respondents mostly agree with (inter)national guideline programmes and literature concerning the criteria important to selecting guideline topics. (Source: Journal of the European Academy of Dermatology and Venereology)
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A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue (Fri, 29 Aug 2014)
ConclusionHLA‐B*58 was associated with GT and HLA‐B*57 was possibly associated with psoriasis. This suggested that some GT cases may represent true oral psoriasis and some may represent only GT. Therefore, it is necessary to make this distinction and increase our sample size to improve the correct diagnosis and treatment of these conditions. (Source: Journal of the European Academy of Dermatology and Venereology)
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Influence of TNF‐α gene polymorphisms in coronary artery calcification in psoriasis patients (Fri, 29 Aug 2014)
(Source: Journal of the European Academy of Dermatology and Venereology)
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Acquired ichthyosis during acitretin therapy for psoriasis vulgaris (Fri, 29 Aug 2014)
(Source: Journal of the European Academy of Dermatology and Venereology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Psoriasis Treatments Are Getting More Personalized (Thu, 28 Aug 2014)
As scientists learn more about psoriasis, more therapeutic options are becoming available for patients with this skin disease. Understanding how psoriasis develops enables them to target different steps in the disease pathway to broaden the types of treatments available. (Source: FDA Consumer Updates)
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Psoriasis: Physical Activity May Reduce Risk, Disease Course Psoriasis: Physical Activity May Reduce Risk, Disease Course (Wed, 27 Aug 2014)
Exercise appeared to decrease the risk of developing psoriasis as well as the severity of disease in a cross-sectional study. Medscape Medical News (Source: Medscape Medical News Headlines)
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The role of neuropeptides in the control of regional immunity (Mon, 25 Aug 2014)
Abstract: Neuropeptides (NPs) and neurotransmitters are a heterogeneous group of soluble factors that make connections within the neuroendocrine and immune systems. NPs, including substance P (SP), vasoactive intestinal peptide (VIP), α melanocyte–stimulating hormone (α-MSH), and calcitonin gene–related peptide (CGRP), released by nerves that innervate the skin, can modulate the action of innate and adaptive skin immunity as well as the skin cells functions. Their role in several inflammatory skin diseases, such as atopic dermatitis, psoriasis, and vitiligo, and in the isotopic response has been reported.Further progress in understanding the various processes that modulate the interactions of the nervous and the skin immune system is essential to develop effective treatment for infla...
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Forthcoming Issues (Mon, 25 Aug 2014)
Psoriasis Alan Menter and Chris Griffiths, Editors (Source: Dermatologic Clinics)
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