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MedWorm: Psoriasis

Amgen Ends Psoriasis-Drug Partnership With AstraZeneca (Sat, 23 May 2015)
Amgen said it is no longer working with AstraZeneca on the co-development of brodalumab, a treatment for conditions including psoriasis, due to safety concerns. (Source: WSJ.com: Health) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Emerging role of long noncoding RNAs in autoimmune diseases (Sat, 23 May 2015)
Publication date: Available online 16 May 2015 Source:Autoimmunity Reviews Author(s): Guo-Cui Wu , Hai-Feng Pan , Rui-Xue Leng , De-Guang Wang , Xiang-Pei Li , Xiao-Mei Li , Dong-Qing Ye Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumato...
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Amgen ends partnership with AstraZeneca on psoriasis drug (Fri, 22 May 2015)
(Reuters) - Amgen Inc said it will terminate a collaboration with AstraZeneca Plc to develop a psoriasis drug after it observed suicidal thoughts in the subjects of a trial. (Source: Reuters: Health)
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Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells. (Fri, 22 May 2015)
Mol. BioSyst., 2015, Accepted ManuscriptDOI: 10.1039/C4MB00739E, PaperKatherine Anne Hollywood, Catherine Winder, Warwick B Dunn, Yun Xu, David Broadhurst, Christopher E.M Griffiths, Royston GoodacrePsoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
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Leukocyte-derived koebnerisin (S100A15) and psoriasin (S100A7) are systemic mediators of inflammation in psoriasis (Fri, 22 May 2015)
(Source: Journal of Dermatological Science)
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Investigation of anti-inflammatory and anti-proliferative activities promoted by photoactivated cationic porphyrin (Fri, 22 May 2015)
Psoriasis is a chronic inflammatory skin disease that affects about 1-3% of the world population. Its etiology seems to be related to genetic susceptibility associated with external stimuli [1], which cause inappropriate activation of the cellular immune system. It is characterized by an excessive proliferation of keratinocytes and a persistent stimulation of the T cells which creates an inflammatory focus, involving both the innate and acquired immune systems. The pathogenicity of psoriasis is mediated by the crosstalk between leukocytes infiltrated (T cells, neutrophils) and skin resident cells through of a variety of proinflammatory mediators such as cytokines, chemokines, growth factors and eicosanoids. (Source: Photodiagnosis and Photodynamic Therapy) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Microscopic Nail Clipping Findings in Patients With Psoriasis (Thu, 21 May 2015)
Conclusions: Nail clippings from patients with psoriasis present abnormally thickened subungual region with prominent hypercorneocytosis, serous lakes, bacteria, neutrophils, and blood collections. If fungi are present, usually there are spores. Clinically, normal-looking nails in patients with psoriasis can present microscopic abnormalities. (Source: The American Journal of Dermatopathology)
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Tests That Diagnose Psoriatic Arthritis (Thu, 21 May 2015)
If you have psoriasis and joint pain, the two may be related. Talk to your doctor about psoriatic arthritis. Learn more at WebMD. (Source: WebMD Health)
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Vulvar dermatoses: a histopathologic review and classification of 183 cases (Thu, 21 May 2015)
ConclusionsOur study has determined the relative frequencies of a wide variety of vulvar dermatoses, and identified new diagnostic clues for early LS, LSC, and Zoon vulvitis. (Source: Journal of Cutaneous Pathology)
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Family history of autoimmune diseases is associated with an increased risk of autism in children: A systematic review and meta-analysis (Thu, 21 May 2015)
Conclusion An overall increased risk of autism in children with family history of ADs was identified. More mechanistic studies are needed to further explain the association between family history of ADs and increased risk of autism in children. (Source: Neuroscience and Biobehavioral Reviews)
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