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MedWorm: Psoriasis

Laser capture microdissection followed by next‐generation sequencing identifies disease‐related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis (Fri, 28 Nov 2014)
In conclusion, we demonstrate that LCM combined with NGS provides a robust approach to explore the global miRNA expression in the epidermal and dermal compartments of psoriatic skin. Furthermore, our results indicate that the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of psoriasis. This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology) MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...
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Matrix based system of isotretinoin as nail lacquer to enhance transungal delivery across human nail plate (Fri, 28 Nov 2014)
Publication date: 15 January 2015 Source:International Journal of Pharmaceutics, Volume 478, Issue 1 Author(s): Monika Joshi , Vijay Sharma , Kamla Pathak The project was aimed at development of isotretinoin nail lacquer and assessment of its penetration efficiency across human nail plate. Preliminary studies (hydration enhancement factor and SEM) aided the selection of thioglycolic acid as permeation and eugenol was selected as local anesthetic in the formulation. The nail lacquer was optimized by 32 factorial design and a total of nine formulations were prepared and screened. In vitro adhesion and ex vivo permeation (cumulative drug permeation per unit area (CDP/A)=6.61±0.57mg/cm2) across bovine hoof guided the selection of F3 as optimized formulation that was improvised. Viscosity ad...
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Dermatological adverse reactions during anti-TNF treatments: Focus on inflammatory bowel disease (Fri, 28 Nov 2014)
Publication date: 1 November 2013 Source:Journal of Crohn's and Colitis, Volume 7, Issue 10 Author(s): Giammarco Mocci , Manuela Marzo , Alfredo Papa , Alessandro Armuzzi , Luisa Guidi The clinical introduction of tumour necrosis factor (TNF) inhibitors has deeply changed the treatment of inflammatory bowel diseases (IBD). It has demonstrated impressive efficacy as compared to alternative treatments, allowing for the chance to achieve near-remission and long-term improvement in function and quality of life and to alter the natural history of Crohn's disease (CD) and ulcerative colitis (UC). As a consequence of longer follow-up periods the number of side effects which may be attributed to treatment with biologics is growing significantly. Cutaneous reactions are among the most common adve...
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Induction or exacerbation of psoriatic lesions during anti-TNF-α therapy for inflammatory bowel disease: A systematic literature review based on 222 cases (Fri, 28 Nov 2014)
Conclusions We found that psoriatic lesions occurred predominantly in adult patients with Crohn's disease who received infliximab and had no previous history of psoriasis. Most patients can be managed conservatively without discontinuing anti-TNF-α therapy. (Source: Journal of Crohns and Colitis)
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GLP-1: benefits beyond pancreas (Thu, 27 Nov 2014)
Conclusion Finally, the GLP-1 has been demonstrated to have a beneficial effect on both vascular, degenerative diseases of central nervous system and psoriasis. (Source: Journal of Endocrinological Investigation)
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Acrodermatitis Continua of Hallopeau Treated Successfully with Ustekinumab and Acitretin after Failure of Tumour Necrosis Factor Blockade and Anakinra (Thu, 27 Nov 2014)
We report herein the case of a 53-year-old patient whose ACH was refractory to all conventional systemic treatment modalities and to anti-tumour necrosis factor. Because he had increased plasma levels of interleukin (IL)-1β, he received anakinra for 7 weeks, without further improvement however. Achievement of complete response was obtained with ustekinumab 90 mg s.c. every 12 weeks combined with acitretin; the plasma level of IL-1β concomitantly returned to normal. This case report is associated with a review on recent data on ACH treatment with biological agents, including anakinra and ustekinumab.Dermatology (Source: Dermatology) MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...
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The role of microRNAs in autoimmune diseases with skin involvement (Thu, 27 Nov 2014)
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
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Are all patients with psoriasis at increased risk for coronary artery disease? (Thu, 27 Nov 2014)
Abstract Associations have been recently recognized between psoriasis and an increased incidence of atherosclerotic diseases. However, there are scarce data on the prevalence of coronary lesions in patients with psoriasis. The aim of this study was to identify the calcified and non‐calcified atherosclerotic coronary lesions in patients with psoriasis compared to controls. Forty patients with psoriasis and 42 control subjects matched for age, sex, and cardiovascular risk profile were included in this case–control study. Coronary lesions were evaluated by a 128‐slice dual source multidetector computed tomography scanner. Coronary calcification scoring was calculated according to the Agatston score. The prevalence of atherosclerotic coronary lesions (psoriasis: 15%, controls: 16.7%; P ...
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Peripheral corneal melting syndrome in psoriatic arthritis treated with adalimumab (Thu, 27 Nov 2014)
We report a 61-year-old man with peripheral corneal melting syndrome associated with psoriatic arthritis who received adalimumab to control skin and ocular inflammation. To our knowledge, this is the first case report of peripheral corneal melting syndrome in psoriatic arthritis treated with adalimumab showing resolution of skin lesions and complete healing of corneal perforation in three months. (Source: Revista Brasileira de Reumatologia)
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How My Wake-Up Call Helped Me Discover My Inner GPS (Wed, 26 Nov 2014)
In Thrive, Arianna Huffington talks about her personal wake-up call: A collapse from exhaustion, a broken cheekbone and a gash over her eye. I had my own wake-up call in May 2013. At the time, it was one of the most frightening and painful experiences of my life; but now looking back, I consider it to be an amazing blessing that changed everything. Upon graduating from college, I started working at a job that was both enriching and challenging. I was determined to be the best, to climb the ladder, to succeed. About once a year, I would have psoriasis outbreaks, a devastating skin condition that would cover my body. It always struck me in the hot New York summers. Instead of spending my time outside with my friends, I would hide my scarred body inside my cool air-conditioned apartment, fi...
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