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MedWorm: Psoriasis

Atherosclerotic disease in axial spondyloarthritis: increased frequency of carotid plaques. (Wed, 27 May 2015)
CONCLUSIONS: Our results confirm the presence of subclinical atherosclerosis in patients with ax-SpA. PMID: 26005760 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Psoriasis (Wed, 27 May 2015)
We describe recent developments in psoriasis epidemiology, pathogenesis, and genetics to better understand present trends in psoriasis management. Our key objective is to raise awareness of the complexity of this multifaceted disease, the potential of state-of-the-art therapeutic approaches, and the need for early diagnosis and comprehensive management of patients with psoriasis. (Source: The Lancet)
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Measuring psoriatic disease in clinical practice. An expert opinion position paper (Wed, 27 May 2015)
Publication date: Available online 27 May 2015 Source:Autoimmunity Reviews Author(s): Ennio Lubrano , Fabrizio Cantini , Antonio Costanzo , Giampiero Girolomoni , Francesca Prignano , Ignazio Olivieri , Raffaele Scarpa , Antonio Spadaro , Fabiola Atzeni , Alessandra Narcisi , Federica Ricceri , Piercarlo Sarzi-Puttini Psoriasis is a common, immune-mediated chronic inflammatory disease with a primary involvement of skin and joints, affecting approximately 2% of the population worldwide. Up to one third of patients with psoriasis are diagnosed with psoriatic arthritis (PsA). Psoriasis and PsA are heterogeneous diseases whose severity depends on a number of clinical factors, such as areas affected and pattern of involvement, and are associated with a range of comorbid diseases and risk fact...
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AstraZeneca hit after psoriasis drug linked to suicide fears (Tue, 26 May 2015)
LONDON (Reuters) - AstraZeneca's hopes of topping $45 billion in revenue by 2023 have been dealt a blow by a problem with an experimental psoriasis drug that the drugmaker had viewed as a potential billion-dollar plus seller. (Source: Reuters: Health)
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Identification of metabolites of PSORALEAE FRUCTUS in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis (Tue, 26 May 2015)
Publication date: 10 August 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 112 Author(s): Pei-le Wang , Zhi-hong Yao , Feng-xiang Zhang , Xiu-yu Shen , Yi Dai , Ling Qin , Xin-sheng Yao The fruit of Psoralea corylifolia (PSORALEAE FRUCTUS) is a traditional Chinese medicine (TCM), which has been used to prevent and treat vitiligo, psoriasis, and osteoporosis in China for thousands of years. Phytochemical investigation on PSORALEAE FRUCTUS, as well as some metabolism research focused on pharmacokinetics of several single compounds from this plant, has been reported. However, the effective material of PSORALEAE FRUCTUS is still unknown. In the present study, the metabolic fate of multiple components of PSORALEAE FRUCTUS in rats was investigated by ultra performance li...
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Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis (Tue, 26 May 2015)
Authors: S Upala & A Sanguankeo (Source: International Journal of Obesity) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Development of bullous pemphigoid during treatment of psoriatic onycho‐pachydermo periostitis with ustekinumab (Mon, 25 May 2015)
Abstract Ustekinumab is a human monoclonal antibody that specifically binds to the p40 subunit of interleukin (IL)‐12 and IL‐23, inhibiting the activity of both cytokines, thereby blocking the T‐helper (Th)1 and Th17 inflammatory pathways. While biologic agents have dramatically changed the strategies of psoriasis treatment, increasing cases of autoimmune diseases during the use of such agents have been reported. We experienced a case of bullous pemphigoid occurring during treatment of a rare variant of psoriatic arthritis, psoriatic onycho‐pachydermo periostitis with ustekinumab. Only six cases of autoimmune blistering diseases during treatment with biologic agents have ever been reported including our case, and we herein review the published work of these cases. Dermatologists mu...
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Meta‐Analysis of Tumor Necrosis Factor Inhibitors and Glucocorticoids on Bone Density in Rheumatoid Arthritis and Ankylosing Spondylitis Trials (Mon, 25 May 2015)
ConclusionIn RA, TNFi and glucocorticoids appeared to attenuate hand bone loss. TNFi did not impact lumbar spine and hip BMD and glucocorticoids had negative effects on lumbar spine and no effect on hip BMD. In AS, TNFi was associated with improved lumbar spine and hip BMD. (Source: Arthritis Care and Research)
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Prevalence of Chronic Axial Pain, Inflammatory Back Pain, and Spondyloarthritis in Diagnosed Psoriasis (Mon, 25 May 2015)
ConclusionThere is a higher prevalence of lower axial pain, IBP, SpA, and alternating buttock pain associated with a prior diagnosis of psoriasis. These data may influence the way psoriasis patients are approached in primary care and specialty clinics. (Source: Arthritis Care and Research)
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The ‘switcher’ patient profile in psoriasis treatment: from traditional to biological and from biological to traditional systemic drugs (Sun, 24 May 2015)
(Source: British Journal of Dermatology)
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