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MedWorm: Psoriasis

Lack of association of vitamin D receptor gene polymorphisms/haplotypes in Sjögren’s syndrome (Mon, 26 Jan 2015)
Abstract The vitamin D is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. Vitamin D has several immunomodulatory effects through vitamin D receptor (VDR). A series of common single-nucleotide polymorphisms (SNPs) in the vitamin D receptor gene have been linked to numerous of diseases, including osteoarthritis, diabetes, cancer, cardiovascular diseases, tuberculosis, virus infections, urinary stones, and periodontitis. Several studies have reported that genetic variations of VDR might be a risk factor for the development of autoimmune diseases such as systemic lupus erythematosus (SLE), multiple sclerosis (MS), psoriasis, and autoimmune thyroid diseases (AITD)... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Tailored approach to early psoriatic arthritis patients: clinical and ultrasonographic predictors for structural joint damage (Mon, 26 Jan 2015)
This study aims to identify the clinical predictors of arthritis in patients with psoriasis and to evaluate the use of musculoskeletal ultrasonography (US) as a predictor for inflammatory structural progression in psoriatic patients. Measures of association (odds ratio (OR)) were tested, in a prospective, cohort 1-year follow-up study, between structural deterioration and the presence of baseline inflammation, or its persistence. One hundred twenty-six psoriatic patients were prospectively evaluated both clinically and by US at 0, 6, and 12 months for synovitis/ joint damage, enthesitis, and onychopathy. X-ray was performed at 0 and 12 months. One hundred twelve sex and age-matched pasoriatic patients without histories of musculoskeletal symptoms were included as control group. Structura...
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Association between Skin and Joint Involvement in Patients with Psoriatic Arthritis Treated with Adalimumab: Analysis of Data from a German Non-Interventional Study (Mon, 26 Jan 2015)
Conclusion: The severity of skin manifestations does not correlate with the severity of joint disease in PsA patients; even patients with mild skin disease may have extensive musculoskeletal involvement.Dermatology (Source: Dermatology)
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Elevated prevalence of Type D (distressed) personality in moderate to severe psoriasis is associated with mood status and quality of life impairment: a comparative pilot study (Mon, 26 Jan 2015)
ConclusionBecause Type D personality could represent a frequent type of personality among individuals with moderate to severe psoriasis, it could serve as a ‘marker’ of more psychologically vulnerable patients, probably related to dysfunctional coping strategies. The Type D personality could represent a profile more frequently encountered among patients with psoriasis, and might therefore help identify subjects physiologically more vulnerable to disease, most likely due to inadequate adaptation mechanisms. (Source: Journal of the European Academy of Dermatology and Venereology)
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Genetic and epigenetic basis of psoriasis pathogenesis (Sun, 25 Jan 2015)
Publication date: April 2015 Source:Molecular Immunology, Volume 64, Issue 2 Author(s): Aditi Chandra , Aditi Ray , Swapan Senapati , Raghunath Chatterjee Psoriasis is a chronic inflammatory skin disease whose prevalence varies among different populations worldwide. It is a complex multi-factorial disease and the exact etiology is largely unknown. Family based studies have indicated a genetic predisposition; however they cannot fully explain the disease pathogenesis. In addition to genetic susceptibility, environmental as well as gender and age related factors were also been found to be associated. Recently, imbalances in epigenetic networks are indicated to be causative elements in psoriasis. The present knowledge of epigenetic involvement, mainly the DNA methylation, chromatin modifica...
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Estimated cost efficacy of systemic treatments that are approved by the US Food and Drug Administration for the treatment of moderate to severe psoriasis (Sun, 25 Jan 2015)
Newer psoriasis treatments tout higher efficacy but are generally more expensive. (Source: Journal of the American Academy of Dermatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Safety Observations in 12095 Patients With Psoriasis Enrolled in an International Registry (PSOLAR): Experience With Infliximab and Other Systemic and Biologic Therapies. (Sat, 24 Jan 2015)
CONCLUSIONS: Based on PSOLAR data through 2013, no new safety concerns were observed with infliximab for all-cause mortality, MACE, or malignancy; the data suggest that infliximab was associated with serious infections.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(12):1441-1448. PMID: 25607786 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Efficacy of botulinum neurotoxin type a for treating recalcitrant plaque psoriasis. (Sat, 24 Jan 2015)
We describe sustained local clearance of a psoriasis plaque in a patient following a single off-label injection of intradermal abobotulinumtoxinA. BoNTA may offer a novel therapeutic approach for treating recalcitrant plaque psoriasis.<br /> Case reports and anecdotal evidence suggests that onabotulinumtoxinA may be useful for treating inverse psoriasis.1,2 We previously reported an improvement in skin phenotype in a preclinical mouse model following a single intradermal injection of abobotulinumtoxinA.3 Here we present a patient case report demonstrating efficacy of abobotulinumtoxinA in reversing plaque psoriasis.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1407-1408. PMID: 25607710 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Real-life treatment profile of calcipotriene and betamethasone dipropionate topical suspension in patients with psoriasis vulgaris. (Sat, 24 Jan 2015)
CONCLUSION: The results of this noninterventional study are consistent with previously reported data from interventional trials and suggest that treatment with CBD topical suspension is efficacious and well tolerated and improves quality of life in patients with psoriasis vulgaris.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1374-1379. PMID: 25607705 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis. (Sat, 24 Jan 2015)
CONCLUSIONS: Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1240-1247. PMID: 25607559 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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