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MedWorm: Psoriasis

Psoriasis: Physical Activity May Reduce Risk, Disease Course Psoriasis: Physical Activity May Reduce Risk, Disease Course (Wed, 27 Aug 2014)
Exercise appeared to decrease the risk of developing psoriasis as well as the severity of disease in a cross-sectional study. Medscape Medical News (Source: Medscape Medical News Headlines) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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The role of neuropeptides in the control of regional immunity (Mon, 25 Aug 2014)
Abstract: Neuropeptides (NPs) and neurotransmitters are a heterogeneous group of soluble factors that make connections within the neuroendocrine and immune systems. NPs, including substance P (SP), vasoactive intestinal peptide (VIP), α melanocyte–stimulating hormone (α-MSH), and calcitonin gene–related peptide (CGRP), released by nerves that innervate the skin, can modulate the action of innate and adaptive skin immunity as well as the skin cells functions. Their role in several inflammatory skin diseases, such as atopic dermatitis, psoriasis, and vitiligo, and in the isotopic response has been reported.Further progress in understanding the various processes that modulate the interactions of the nervous and the skin immune system is essential to develop effective treatment for infla...
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Forthcoming Issues (Mon, 25 Aug 2014)
Psoriasis Alan Menter and Chris Griffiths, Editors (Source: Dermatologic Clinics)
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Anti-psoriatic activity of flavonoids from Cassia tora leaves using the rat ultraviolet B ray photodermatitis model (Fri, 22 Aug 2014)
The plant Cassia tora L., Fabaceae, traditionally, is claimed to be useful in the treatment of psoriasis and other skin diseases. In order to evaluate this information, antipsoriatic activity of three flavonoids, namely luteolin-7-O-β-glucopyranoside (1), quercetin-3-O-β-D-glucuronide (2) and formononetin-7-O-β-D-glucoside (3), isolated from the ethanol extract of C. tora leaves were investigated using UV-B induced photodermatitis model. Further, the flavonoids present in the ethanol extract were identified using HPLC by comparing their retention time with known standard luteolin, quercetin and formononetin. In the UV induced photodermatitis model, histopathological analysis of the section revealed the absence of Munro's microabscess, elongation of rete ridges, and capillary loop dilati...
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Oral Ponesimod Relieves Chronic Plaque PsoriasisOral Ponesimod Relieves Chronic Plaque Psoriasis (Fri, 22 Aug 2014)
Ponesimod, an oral selective modulator of the sphingosine 1-phosphate receptor, yielded significant clinical benefit in a phase 2 trial of patients with moderate to severe chronic plaque psoriasis. Reuters Health Information (Source: Medscape Medical News Headlines)
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Sitagliptin for severe psoriasis (Fri, 22 Aug 2014)
(Source: Clinical And Experimental Dermatology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Psoriasiform exfoliative erythroderma induced by golimumab (Fri, 22 Aug 2014)
Summary Golimumab is a fully human anti‐tumour necrosis factor (TNF)‐α monoclonal antibody approved for use in the treatment of active rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Psoriasis induced by treatment with anti‐TNF drugs is well documented, but to our knowledge, the development of clinical features of psoriasiform exfoliative erythroderma during treatment with golimumab has not been previously described. (Source: Clinical And Experimental Dermatology)
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Familial aggregation of moderate to severe plaque psoriasis (Fri, 22 Aug 2014)
ConclusionsThese results show a high familial recurrence risk of psoriasis, and suggest a balanced parental transmission of the disease. (Source: Clinical And Experimental Dermatology)
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Lilly Psoriasis Drug Succeeds in Late-Stage StudiesLilly Psoriasis Drug Succeeds in Late-Stage Studies (Thu, 21 Aug 2014)
Eli Lilly and Co said its experimental psoriasis drug was found to be more effective in clearing skin than a generic treatment and a placebo in late-stage studies. Reuters Health Information (Source: Medscape Medical News Headlines)
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Lilly psoriasis drug impresses; battle nears with Amgen, Novartis (Thu, 21 Aug 2014)
(Reuters) - An experimental new psoriasis treatment from Eli Lilly and Co proved superior to Amgen Inc's blockbuster Enbrel, drawing it closer to a potential marketing battle with new products being developed by Amgen and Novartis AG. (Source: Reuters: Health)
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