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MedWorm: Psoriasis

Comorbidities and cardiovascular risk factors in patients with psoriasis (Tue, 02 Sep 2014)
CONCLUSIONS: Patients had high prevalence of cardiovascular comorbidities, and high cardiovascular risk according to the Framingham risk score. Further epidemiological studies are needed in Brazil for validation of our results. (Source: Anais Brasileiros de Dermatologia) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Case for diagnosis (Tue, 02 Sep 2014)
We report the case of a patient with ostraceous psoriasis treated with methotrexate. (Source: Anais Brasileiros de Dermatologia)
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Correlation between psoriasis' severity and waist-to-height ratio (Tue, 02 Sep 2014)
In the absence of ideal biomarkers, the research for clinical markers correlated to the severity of psoriasis and/or its comorbidities becomes crucial. Recently, studies have shown positive correlation between body mass index and prevalence and severity of psoriasis. Abdominal circumference showed stronger correlation with disease severity than body mass index. We evaluated the waist-to-height ratio in a sample of 297 adult patients with psoriasis and observed that it has a significant correlation with body mass index and PASI, and together with body mass index allows the identification of central obesity, reducing its subdiagnosis. (Source: Anais Brasileiros de Dermatologia)
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Cyclosporine is Superior to Tacrolimus in Liver Transplant Recipients with Recurrent Psoriasis. (Mon, 01 Sep 2014)
Conclusions PS may relapse after LT despite IS, concomitant AID may be the main predisposing factor to disease relapses, and CsA seems to be more potent than TAC for treating rPS in LTR. PMID: 25163829 [PubMed - in process] (Source: Annals of Transplantation)
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Patent watch: Stelara safe after IL-12 antibody dispute (Mon, 01 Sep 2014)
Nature Reviews Drug Discovery 13, 647 (2014). doi:10.1038/nrd4423 Author: Charlotte Harrison AbbVie has lost a patent dispute in which it tried to show that Janssen's Stelara (ustekinumab) — an antibody binding to interleukin-12 (IL-12) and IL-23 that is marketed for the treatment of psoriasis and psoriatic arthritis — infringed on two patents describing IL-12-targeting antibodies owned (Source: Nature Reviews Drug Discovery)
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Psoriasis sparing the polio-affected limb: Is it merely the koebner phenomenon? (Mon, 01 Sep 2014)
We report a case of an adult male, who presented with psoriasis distributed all over the body but with almost complete sparing of the polio-affected left lower limb. (Source: Indian Journal of Dermatology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Severity of psoriasis among adult males is associated with smoking, not with alcohol use (Mon, 01 Sep 2014)
James KH Ho, John HG AntrumIndian Journal of Dermatology 2014 59(5):516-516 (Source: Indian Journal of Dermatology)
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Addition of cyclosporine to adalimumab improved psoriasis and adalimumab-induced injection site reaction (Mon, 01 Sep 2014)
Satoshi Nakamizo, Yoshiki Miyachi, Kenji KabashimaIndian Journal of Dermatology 2014 59(5):522-523 (Source: Indian Journal of Dermatology)
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Risk of tuberculosis with the use of anti-TNF medications in psoriasis: incidence, screening and management. (Fri, 29 Aug 2014)
Authors: Kasiraman V, Atwan AA, Durojaiye OC, Kalavala M, Piguet V Abstract Tumor necrosis factor (TNF) plays an important role in containing mycobacterial infections. With the rapidly increasing role of TNF inhibitors in dermatology, tuberculosis (TB) is becoming an important and worrisome concern to dermatologists. This paper aims to provide a comprehensive review on the incidence of TB in patients treated with anti-TNF, the variety of TB screening methods, and management of these cases. Various national recommendations have been highlighted. The monoclonal antibodies, infliximab and adalimumab, appear to be more associated with the risk of TB reactivation than the soluble receptor etanercept. Tuberculosis associated with TNF inhibitors, in contrast to classical TB, is more likel...
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Social impact of the burden of psoriasis: effects on patients and practice. (Fri, 29 Aug 2014)
Authors: Feldman SR, Malakouti M, Koo JY Abstract The raised, scaly, and erythematous plaques associated with psoriasis can be cosmetically disfiguring, which may provoke disgust, fear, and aversion in others. Consequently, the social stigma of psoriasis can be devastating for patients, evoking feelings of shame and anxiety about how they are perceived. In recent years, appreciation of psoriasis as a disease that can cause social distress and impairment has increased. This review discusses the manifold social burdens of psoriasis; different and emerging therapies that may mitigate these burdens by improving outcomes associated with the underlying disease; and psoriasis management in the context of healthcare reform changes focused on assessing the quality and value of patient care....
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