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MedWorm: Psoriasis

Association between methylenetetrahydrofolate reductase C677T polymorphism and psoriasis: A meta‐analysis (Mon, 27 Jul 2015)
In conclusion, MTHFR C677T polymorphism, qualitatively, is not a genetic factor for the pathogenesis of psoriasis but could quantitatively reflect the severity of psoriasis to some extent. (Source: The Journal of Dermatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. (Sat, 25 Jul 2015)
Authors: Biava PM, Canaider S, Facchin F, Bianconi E, Ljungberg L, Rotilio D, Burigana F, Ventura C Abstract In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathologic...
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p53 activity contributes to defective interfollicular epidermal differentiation, in hyperproliferative murine skin (Fri, 24 Jul 2015)
ConclusionWe conclude aberrant non‐apoptotic p53 activity contributes, in‐part, to abnormal differentiation and granular layer defects.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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Reply (Fri, 24 Jul 2015)
I read the correspondence by Yamanaka and Mizutani1 with great interest. Our previous findings of increased cardiovascular risk factors in adult atopic dermatitis (AD) in the US population2 raise intriguing questions about the potential mechanisms of such association. It is possible that chronic systemic inflammation may play a role in driving cardiovascular disease in some patients with AD. This is reminiscent to the increased cardiovascular risk that is now well established in psoriasis. The inflammatory pathways that have been previously implicated in psoriasis and may also contribute to cardiovascular disease are IL-20, IL-22, IL-17, and TNF-α (reviewed in Shlyankevich et al3). (Source: Journal of Allergy and Clinical Immunology)
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“Inflammatory skin march”: IL-1–mediated skin inflammation, atopic dermatitis, and psoriasis to cardiovascular events (Fri, 24 Jul 2015)
Recently, Silverberg and Greenland1 declared the increased risk for cardiovascular events in adult patients with severe eczema, emphasizing the importance of more aggressive interventions for eczema. The itching affects the whole body in patients with severe atopic dermatitis (AD) and induces intensive scratching of the skin lesions. The skin damaged by scratching and eczematous inflammation releases a massive amount of the proinflammatory cytokines stored in the epidermis into the systemic circulation targeting the distant organs. (Source: Journal of Allergy and Clinical Immunology)
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Early Alefacept in Type 1 Diabetes Shows Benefit at 2 Years Early Alefacept in Type 1 Diabetes Shows Benefit at 2 Years (Fri, 24 Jul 2015)
Formerly sold as a psoriasis treatment, a study of the agent in newly diagnosed patients demonstrates the feasibility of preserving beta-cell function by inducing immune tolerance, say researchers. Medscape Medical News (Source: Medscape Medical News Headlines) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Contribution of the IL-17 Pathway to Psoriasis and Psoriatic Arthritis (Fri, 24 Jul 2015)
Abstract Investigators have accrued compelling evidence that the IL-17 pathway is central to the pathogenesis of psoriasis and psoriatic arthritis. The evidence comprises genome-wide association studies (GWAS), data from experimental murine models and findings from in vitro studies on patients’ cells or tissue biopsies. More recently, the success of drugs blocking the IL-17 pathway in treating both psoriasis (PsO) and psoriatic arthritis (PsA) confirms that IL-17 is a clinically relevant therapeutic target. However, there remain many unanswered questions: is PsA simply an extension of PsO from the skin to the synovial tissue or are there differences in the underlying pathogenesis of these diseases? Which cell type represents the primary source of IL-17 in PsO and PsA? And how a...
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Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients. (Fri, 24 Jul 2015)
Authors: Brunoni AR, Lotufo PA, Sabbag C, Goulart AC, Santos IS, Benseñor IM Abstract Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n=94) presenting with psoriasis for at least 1 year were enrolled, and age- and gender-matched with healthy controls (n=307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major ...
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Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling (Thu, 23 Jul 2015)
In this report, we describe a 65-year-old Japanese man with psoriasiform drug eruption caused by abatacept. Interestingly, immunohistochemical staining revealed that the epidermal keratinocytes in the basal layer and lower layers of the stratum spinosum were positive for pSTAT3, partially positive for pSTAT1 and negative for pSTAT6, which is similar to conventional psoriasis vulgaris. Our present study suggests that psoriasiform drug eruption caused by abatacept might develop by similar immunological mechanisms as those of psoriasis vulgaris.Case Rep Dermatol 2015;7:166-170 (Source: Case Reports in Dermatology)
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National Psoriasis Foundation launches online patient-centered research network (Thu, 23 Jul 2015)
(National Psoriasis Foundation) For the first time, people with psoriasis and psoriatic arthritis can contribute directly to the future of research into these chronic, systemic autoimmune diseases through the National Psoriasis Foundation's patient-centered research network called Citizen Pscientist. An online, interactive community, Citizen Pscientist allows people living with psoriatic disease to connect with researchers, share their data and get input from others in the community, and ultimately drive the direction of psoriatic disease research. Learn more at www.citizenpscientist.org. (Source: EurekAlert! - Medicine and Health)
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