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MedWorm: Psoriasis

IL-36γ Sustains a Proinflammatory Self-amplifying Loop with IL-17C in Anti-TNF–induced Psoriasiform Skin Lesions of Patients with Crohn's Disease (Fri, 24 Oct 2014)
Conclusions:Our study demonstrates a unique role of the previously unknown self-amplifying, proinflammatory IL-36γ/IL-17C loop in the pathogenesis of anti-TNF–induced psoriasiform skin lesions. These findings suggest a beneficial effect of IL-36γ/IL-17C inhibition during anti-TNF–induced psoriasiform lesions in patients with inflammatory bowel disease. (Source: Inflammatory Bowel Diseases) MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...
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Systemic treatments in paediatric psoriasis: a systematic evidence‐based update (Thu, 23 Oct 2014)
Abstract In 2008, a systematic review revealed that evidence‐based data on efficacy and safety of treatments in paediatric psoriasis are scarce and with low level of evidence. In recent years, publications on this topic have increased exponentially. To present a systematic, evidence‐based update on the efficacy and safety of systemic treatments in paediatric psoriasis and to provide treatment recommendations, an update of the previous review was performed. PubMed, EMBASE and the Cochrane Controlled Clinical Trial Register were searched between January 2007 and March 2014 for all available literature on efficacy and safety of all systemic treatments in paediatric psoriasis. The levels of evidence were determined on the Oxford Centre for Evidence‐based Medicine Levels of Evidence. The ...
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Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications (Thu, 23 Oct 2014)
Publication date: February 2014 Source:Acupuncture and Related Therapies, Volume 2, Issue 1 Author(s): Tiziana Parasassi , Roberto Brunelli , Ewa K. Krasnowska , Thomas Lundeberg , Eugenia Pittaluga , Maria Concetta Romano Increasing evidences attribute a central role to oxidation/reduction (redox) homeostasis in controlling cell physiology, with redox transitions of glutathione and sensitive cysteines in protein constituting the major players. Thiol redox control of protein activity and gene expression ultimately extends to the proliferation/differentiation switch. Several diseases, including the highest causes of mortality, have been attributed to a shift toward a more oxidized environment. Interfering with thiol redox transitions in diseases therefore appears a major clinical objectiv...
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Psoriasis in Pregnancy: A Review (i) (Thu, 23 Oct 2014)
Publication date: October 2014 Source:Actas Dermo-Sifiliográficas (English Edition), Volume 105, Issue 8 Author(s): V. Ruiz , E. Manubens , L. Puig Psoriasis is a complex inflammatory disease, and in women the incidence is high in child-bearing years. Treatment during pregnancy presents genuine challenges since management requires adequate assessment of the extent of disease, comorbidity, and potential risk to the fetus. Scientific evidence is scarce on the effects that certain drugs have on fetal development given the ethical concerns about enrolling pregnant women in clinical trials. This review presents up-to-date information on the course of psoriasis during gestation and discusses associated conditions and the therapeutic protocols recommended for use during pregnancy. (Source: Act...
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Clinical Management of Paradoxical Psoriasiform Reactions During TNF-α Therapy (Thu, 23 Oct 2014)
Publication date: October 2014 Source:Actas Dermo-Sifiliográficas (English Edition), Volume 105, Issue 8 Author(s): R. Navarro , E. Daudén There have been reports of paradoxical induction or worsening of psoriasis during treatment with tumor necrosis factor (TNF) α agents (infliximab, etanercept, adalimumab, and certolizumab). It has been hypothesized that an imbalance between TNF-α and interferon α might have a role in the etiology and pathogenesis of these reactions. Paradoxical psoriasiform reactions can be divided clinically into de novo psoriasis and exacerbation of preexisting psoriasis. The first, which is more common and more extensively described in the literature, occurs in patients without a history of psoriasis who are receiving TNF-α therapy for another inflammatory di...
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Psoriasis In Pregnancy: A Review. Part 2 (Thu, 23 Oct 2014)
Publication date: Available online 1 October 2014 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): V. Ruiz , E. Manubens , L. Puig Scarce scientific evidence is available to define the precise effects that certain drugs might have on embryonic and fetal development if taken by pregnant women with psoriasis, given the ethical concerns that preclude enrolling such women in clinical trials. The little information on the use of biologics during gestation that has been published is based on retrospective and observational studies, and experience with these drugs in this context in psoriasis is still very limited. The literature seems to suggest that biologic therapy is safe during pregnancy, but there is no certainty. This detailed review of accumulated experience with biologi... MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...
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Prolonged remission of psoriasis with azathioprine pulse therapy (Thu, 23 Oct 2014)
Conclusions Out of 45 patients in phase IV, 25 patients are in continuous remission for more than 3 years (maximum 93 months), 9 are in remission for 1–3 years, while 11 are less than 1 year in continuous remission after all treatment was stopped. Thus azathioprine pulse therapy regimen produced prolonged remission in psoriasis. (Source: Apollo Medicine)
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Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier (Thu, 23 Oct 2014)
by Tia DiTommaso, Denny L. Cottle, Helen B. Pearson, Holger Schlüter, Pritinder Kaur, Patrick O. Humbert, Ian M. Smyth Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice. Homozygous disruption of this epidermally expressed gene causes neonatal skin flaking, hyperpigmentation, inflammation, impaired wound healing, and death prior to 12 weeks of age. We show that this phenotype is associated with functionally defective tight junctions that are characterised by mislocalization of the integral protein CLDN1. We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly po...
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Ischemic cardiovascular involvement in psoriasis: A systematic review (Thu, 23 Oct 2014)
Epidemiologic studies demonstrate that psoriasis is associated with shorter life expectancy, most frequently attributable to cardiovascular (CV) events. Although increased prevalence and incidence of CV risk factors for atherosclerosis have been reported in psoriatic patients, psoriasis likely plays an independent role in the increased cardiovascular risk, presumably linked to the chronic systemic inflammatory state. Consistently, preliminary investigations suggest that anti-inflammatory therapies may improve early subclinical vascular alterations and reduce cardiovascular morbidity and mortality. (Source: International Journal of Cardiology)
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Genetic variations of NLRP1: susceptibility in psoriasis (Wed, 22 Oct 2014)
ConclusionsOur data support the involvement of NLRP1 and the NLRP1 inflammasome in psoriasis susceptibility and further support the role of innate immunity in psoriasis. (Source: British Journal of Dermatology)
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