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MedWorm: Psoriasis

Endogenous animal toxin-like human β-defensin 2 inhibits own K(+) channels through interaction with channel extracellular pore region. (Sat, 20 Sep 2014)
In this study, we demonstrate for the first time using electrophysiological techniques, that endogenous human β-defensin 2 (hBD2) is able to selectively and dose-dependently inhibit the human voltage-gated Kv1.3 channel at picomolar peptide concentration. The co-immunoprecipitation assays further supported the selective binding of hBD2 to Kv1.3 channel. Using mutagenesis experiments, we found that the outer pore domain of Kv1.3 channel was the binding site of hBD2, which is similar to the interacting site of Kv1.3 channel recognized by animal toxin inhibitors. The hBD2 was able to suppress IL-2 production through inhibition of Kv1.3 channel currents in human Jurkat cells, which was further confirmed by the lack of hBD2 activity on IL-2 production after Kv1.3 knockdown in these cells. More... MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Increased prevalence of psoriasis in patients with coronary artery disease (Fri, 19 Sep 2014)
ORIGINAL ARTICLE, p 580 (Source: British Journal of Dermatology)
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Providing lifestyle behaviour change support for patients with psoriasis: an assessment of the existing training competencies across medical and nursing health professionals (Fri, 19 Sep 2014)
ORIGINAL ARTICLE, p 602 (Source: British Journal of Dermatology)
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Sun Pharma and Merck partner for plaque psoriasis drug candidate tildrakizumab (Fri, 19 Sep 2014)
India-based Sun Pharma has signed an exclusive worldwide licensing agreement with US-based Merck for its investigational therapeutic antibody candidate, tildrakizumab (MK-3222). (Source: Pharmaceutical Technology)
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Serum amyloid A Induces IL‐1β secretion from keratinocytes via the NLRP3 Inflammasome (Thu, 18 Sep 2014)
In this study, we detected increased SAA mRNA and protein expression in psoriatic epidermis. In cultured keratinocytes, SAA upregulated the expression of pro‐IL‐1β and secretion of mature IL‐1β. On the transcriptional level, blocking Toll‐like receptor 2 (TLR2), TLR4 or NF‐κB attenuated SAA‐induced expression of IL‐1β mRNA. SAA upregulated caspase‐1 and NLRP3 expression in keratinocytes. Inhibiting caspase‐1 activity and silencing NLRP3 decreased IL‐1β secretion, confirming NLRP3 as the SAA‐responsive inflammasome on the post‐transcriptional level. The mechanism of SAA‐triggered NLRP3 activation and subsequent IL‐1β secretion was found to involve the generation of reactive oxygen species. Finally, the expression of SAA by keratinocytes was upregulated by I...
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Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS (Thu, 18 Sep 2014)
We present BlocBuster, a novel systems-level approach that efficiently constructs genome-wide, allele-specific networks that accurately segregate homogenous combinations of genetic factors, tests the associations of these combinations with the given phenotype, and rigorously validates the results using a series of unbiased validation methods. BlocBuster employs a correlation measure that is customized for single nucleotide polymorphisms and returns a multi-faceted collection of values that captures genetic heterogeneity. We applied BlocBuster to analyze psoriasis, discovering a combinatorial pattern with an odds ratio of 3.64 and Bonferroni-corrected p-value of 5.01×10−16. This pattern was replicated in independent data, reflecting robustness of the method. In addition to improving pred... MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Merck licenses experimental psoriasis drug to Sun Pharma (Wed, 17 Sep 2014)
Merck & Co Inc said it had licensed its experimental psoriasis drug to generic maker Sun Pharmaceutical Industries Ltd for $80 million. (Source: The Economic Times Healthcare and Biotech News)
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Sick Days Decreased in Psoriasis Patients on EtanerceptSick Days Decreased in Psoriasis Patients on Etanercept (Wed, 17 Sep 2014)
This study examined the economic effect of etanercept therapy on patients with psoriasis and psoriatic arthritis. Can it reduce missed work days and improve employment outcomes? BMC Dermatology (Source: Medscape Today Headlines)
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Results of the validation study of the Psodisk instrument, and determination of the cut‐off scores for varying degrees of impairment (Wed, 17 Sep 2014)
ConclusionThe Psodisk showed good psychometric properties. The definition of the cut‐off scores will be useful to evaluate the burden of psoriasis on patients. (Source: Journal of the European Academy of Dermatology and Venereology)
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Pruritus in Psoriasis: A Study of Personality Traits, Depression and Anxiety. (Wed, 17 Sep 2014)
In this study of 101 patients with plaque psoriasis, those with severe pruritus reported significantly higher scores for both depression and anxiety. Using the Swedish universities Scales of Personality, 4 personality traits were significantly associated with severe pruritus: Somatic trait anxiety, Embitterment, Mistrust, and Physical trait aggression. These results indicate that patients with psoriasis and severe pruritus might have a more vulnerable psychological constitution. This suggests important opportunities for clinicians to identify patients who could benefit from psychological interventions. PMID: 25229695 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
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