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MedWorm: Psoriasis

Interleukin-23 in the pathogenesis and treatment of psoriasis. (Sat, 28 Mar 2015)
Authors: Kollipara R, Downing C, Gordon R, Tyring S Abstract In the past three decades, major advances have been made in understanding the pathogenesis of psoriasis. The currently accepted theory is that T-cell mediated immune dysregulation triggers keratinocyte hyperproliferation in psoriasis. Recent research indicates that the Th17/interleukin (IL)-23 pathway plays a prominent role in the amplification phase of psoriasis. The discovery of the Th17/ IL-23 pathway provides targets for new drug development. This review focuses on the role of IL-23 in psoriasis pathogenesis and the current therapies targeting IL-23 that are in clinical trials. PMID: 25807335 [PubMed - in process] (Source: Skin Therapy Letter) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Subclinical Atherosclerosis in Patients with Psoriasis (Sat, 28 Mar 2015)
Publication date: Available online 28 March 2015 Source:Journal of the Saudi Heart Association Author(s): Ilknur Balta , Sevket Balta , Ibrahim Karademir , Sait Demirkol , Cengiz Ozturk , Turgay Celik (Source: Journal of the Saudi Heart Association)
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Biologics Take Aim at Psoriasis Despite Worry Over ReactionsBiologics Take Aim at Psoriasis Despite Worry Over Reactions (Fri, 27 Mar 2015)
The oral drug tofacitinib, typically prescribed for rheumatoid arthritis, is showing promise for the treatment of psoriasis, and new experimental agents are gaining ground. Medscape Medical News (Source: Medscape Dermatology Headlines)
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(320) Neurotrophic factors selectively modulate scratching behavior and sensory neuron responses to pruritogens (Fri, 27 Mar 2015)
Skin biopsies from patients with atopic dermatitis or psoriasis exhibit increased intraepidermal nerve fiber density, increased glial cell line-derived neurotrophic factor (GDNF) and artemin, and increased nerve growth factor (NGF) and its receptor TrkA. Additionally, we have recently demonstrated a selective increase in Ret+ fibers in a mouse model of dry skin itch. These data indicate that neurotrophic factors (NTFs) contribute to the development and maintenance of chronic itch. In our current studies we investigated whether NGF and the GDNF family ligands (GFLs) GDNF, neurturin, and artemin can directly induce or modulate histaminergic and non-histaminergic itch. (Source: The Journal of Pain)
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Disturbed postprandial glucose metabolism and gut hormone responses in non‐diabetic patients with psoriasis (Fri, 27 Mar 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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Brain inflammation and psoriasis: a [11C]‐(R)‐PK11195 positron emission tomography study (Fri, 27 Mar 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: Application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study (Fri, 27 Mar 2015)
Publication date: 15 May 2015 Source:International Journal of Pharmaceutics, Volume 485, Issues 1–2 Author(s): Aly A. Abdelbary , Mohamed H.H. AbouGhaly Psoriasis, a skin disorder characterized by impaired epidermal differentiation, is regularly treated by systemic methotrexate (MTX), an effective cytotoxic drug but with numerous side effects. The aim of this work was to design topical MTX loaded niosomes for management of psoriasis to avoid systemic toxicity. To achieve this goal, MTX niosomes were prepared by thin film hydration technique. A Box-Behnken (BB) design, using Design-Expert® software, was employed to statistically optimize formulation variables. Three independent variables were evaluated: MTX concentration in hydration medium (X 1), total weight of niosomal components (X...
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Randomized Controlled Trial of Adalimumab in Patients With Nonpsoriatic Peripheral Spondyloarthritis (Fri, 27 Mar 2015)
ConclusionTreatment with adalimumab ameliorated the signs and symptoms of disease and improved physical function in patients with active nonpsoriatic peripheral SpA who exhibited an inadequate response or intolerance to NSAIDs, with a safety profile consistent with that observed in patients with AS, PsA, or other immune‐mediated diseases. (Source: Arthritis and Rheumatism)
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An evaluation of the preferences of patients with psoriasis between systemic psoralen plus ultraviolet A and bath psoralen plus ultraviolet A (Fri, 27 Mar 2015)
(Source: British Journal of Dermatology)
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Osteopontin deficiency affects imiquimod‐induced psoriasis‐like murine skin inflammation and lymphocyte distribution in skin, draining lymph nodes and spleen (Fri, 27 Mar 2015)
In conclusion, OPN may modulate psoriasis‐like inflammation through altering lymphocyte distribution in skin and draining lymph nodes and by inducing IL‐17 expression of inflammatory T cells. (Source: Experimental Dermatology)
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