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MedWorm: Psoriasis

In silico database screening of potential targets and pathways of compounds contained in plants used for psoriasis vulgaris (Sat, 04 Jul 2015)
Abstract Reviews and meta-analyses of clinical trials identified plants used as traditional medicines (TMs) that show promise for psoriasis. These include Rehmannia glutinosa, Camptotheca acuminata, Indigo naturalis and Salvia miltiorrhiza. Compounds contained in these TMs have shown activities of relevance to psoriasis in experimental models. To further investigate the likely mechanisms of action of the multiple compounds in these TMs, we undertook a computer-based in silico investigation of the proteins known to be regulated by these compounds and their associated biological pathways. The proteins reportedly regulated by compounds in these four TMs were identified using the HIT (Herbal Ingredients' Targets) database. The resultant data were entered into the PANTHER (Protein AN... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Metabolic syndrome in psoriasis patients. Residual inflammation and pro‐inflammatory IL17 signaling reduce length of remission. A follow‐up study (Sat, 04 Jul 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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A tale of two sisters: identical IL36RN mutations and discordant phenotypes (Sat, 04 Jul 2015)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
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Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation (Sat, 04 Jul 2015)
Publication date: Available online 3 July 2015 Source:Pharmacological Research Author(s): Ahmed Nadeem , Naif O. Al-Harbi , Mohamed M. Al-Harbi , Ahmed M. El-Sherbeeny , Sheikh F. Ahmad , Nahid Siddiqui , Mushtaq A. Ansari , Khairy M.A. Zoheir , Sabry M. Attia , Khaled A. Al-Hosaini , Shakir D. Al-Sharary Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of psoriasis. The small molecule bromodomain and extraterminal domain (BET) inhibitors, that disrupt interaction of BET proteins with acetylated histones have recently demonstr...
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Exclusive: Hospira wins French biosimilar drug tender at 45 percent discount (Fri, 03 Jul 2015)
PARIS (Reuters) - A major French hospital group has chosen a cheap copycat version of a top-selling drug for treating its patients with rheumatoid arthritis, Crohn's disease and psoriasis in a victory for a new type of medicine known as biosimilars.    (Source: Reuters: Health)
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A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis (Fri, 03 Jul 2015)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Skin disorders in elderly subjects (Fri, 03 Jul 2015)
ConclusionsSkin disorders are common in elderly people. Systemic diseases promote the development of dermatological conditions. A comprehensive approach to health problems in elderly subjects requires knowledge of dermatology. (Source: International Journal of Dermatology)
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Trauma Flagged as Trigger for Arthritis in Psoriasis PatientsTrauma Flagged as Trigger for Arthritis in Psoriasis Patients (Thu, 02 Jul 2015)
In patients with psoriasis, trauma, in particular bone and joint trauma, has been identified as a robust risk factor for the development of psoriatic arthritis. Medscape Medical News (Source: Medscape Medical News Headlines)
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Programmed death-ligand 1, 2 expressions are decreased in the psoriatic epidermis (Thu, 02 Jul 2015)
In conclusion, we demonstrated that PD-L1, 2 are decreased in psoriatic epidermis in mRNA and protein levels. In addition, we showed that their expression was significantly lower than other inflammatory skin diseases. We suggest that decreased expression of PD-L1, 2 on psoriatic epidermis can contribute to its chronic unregulated inflammatory characteristics. (Source: Archives of Dermatological Research)
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Activated group 3 innate lymphoid cells are selectively enriched in psoriatic arthritis synovial fluid (Thu, 02 Jul 2015)
Conclusion: PsA synovial fluid is enriched for ILC3 that express CCR6 and NKp44, which distinguishes the synovial compartment from RA. The increased IL‐17A production by SF ILCs implicates a novel role for ILCs in PsA. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
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