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MedWorm: Psoriasis

Prurigo Pigmentosa: A Clinicopathologic Study of 4 Cases From the Middle East (Wed, 01 Oct 2014)
Abstract:Prurigo pigmentosa (PP) is a rare inflammatory dermatosis originally reported in Japan. Since then, most reports have originated from Asia, and to a lesser extent from Europe. Although the pathogenesis remains unclear, it is now established that PP is linked to ketoacidotic states. Four patients diagnosed with PP were identified from the dermatopathology database at the American University of Beirut Medical Center between January 2009 and December 2013. Clinicopathologic findings in the 4 patients were similar to those previously reported in the literature. The patients were all female with a mean age of 23.5 years. They all presented with itchy erythematous reticulated papulovesicles/plaques leaving variable reticulated brownish patches. Two patients had, in addition, annular les... MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Neutrophil‐to‐Lymphocyte Ratio May Predict Subclinical Atherosclerosis in Patients with Psoriasis (Wed, 01 Oct 2014)
(Source: Echocardiography)
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Regulated genes in psoriatic skin during treatment with fumaric acid esters (Tue, 30 Sep 2014)
ConclusionsFAE treatment induces glutathione and Nrf2 pathway genes in lesional skin of patients with psoriasis. In responders, FAEs specifically regulate the transcription factors PTTG1, NR3C1, GATA3 and NFκBIZ, which are important in normal cutaneous development, and the T‐helper (Th)2 and Th17 pathways, respectively. (Source: British Journal of Dermatology)
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Downregulation of involucrin in psoriatic lesions following therapy with propylthiouracil, an anti‐thyroid thioureylene: immunohistochemistry and gene expression analysis (Tue, 30 Sep 2014)
ConclusionsIn psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. The therapeutic effect of PTU in psoriasis may be attributable to the downregulation of involucrin. Larger trials should further elucidate the mechanism and therapeutic potential of PTU in psoriasis. (Source: International Journal of Dermatology)
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Quality of life and related factors in a cohort of plaque‐type psoriasis patients in La Coruña, Spain (Tue, 30 Sep 2014)
ConclusionsFactors associated with greater impairment of QoL were gender, psoriasis duration, and type of treatment. Patients receiving systemic and biologic therapies reported better QoL. (Source: International Journal of Dermatology)
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Are patients with mild to moderate psoriasis more physically active than healthy controls? Comments on the study by Demirel et al. (Tue, 30 Sep 2014)
(Source: International Journal of Dermatology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Membrane and soluble Toll‐like receptor 2 in patients with psoriasis treated by Goeckerman therapy (Tue, 30 Sep 2014)
ConclusionsMembrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT. (Source: International Journal of Dermatology)
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Evaluation of body composition parameters in patients with psoriasis (Tue, 30 Sep 2014)
ConclusionsThe present study provides evidence of a relationship between some body composition parameters and the occurrence of psoriasis. We suggest that body composition parameters should be analyzed not only in obese psoriasis patients but in all psoriasis patients upon their first diagnosis. Systemic therapy does not appear to cause any changes in body composition parameters. (Source: International Journal of Dermatology)
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Latent tuberculosis infection in patients with chronic plaque psoriasis who are candidates for biological therapy (Tue, 30 Sep 2014)
ConclusionsThe prevalence of LTBI in patients with psoriasis is similar to that in patients with Crohn disease or RA and in healthcare workers. Prophylaxis with isoniazid is effective in preventing tuberculosis reactivation in patients with LTBI receiving biological therapy. (Source: British Journal of Dermatology)
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Distribution Pattern of Psoriasis Affects Sexual Function in Moderate to Severe Psoriasis: A Prospective Case Series Study (Mon, 29 Sep 2014)
ConclusionsThis is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when deciding on treatment for psoriasis patients. Molina‐Leyva A, Almodovar‐Real A, Ruiz‐Carrascosa JC, Naranjo‐Sintes R, Serrano‐Ortega S, and Jimenez‐Moleon JJ. Distribution pattern of psoriasis affects sexual function in moderate to severe psoriasis: A prospective case series study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)
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