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MedWorm: Psoriasis

New psoriatic arthritis screening tool passes initial validation (Fri, 17 Apr 2015)
The second version of the Toronto Psoriatic Arthritis screen performed well at identifying psoriatic arthritis in 336 psoriasis patients, 131 psoriatic arthritis patients, and 89 individuals in the general population, according to Dr. Brian Tom and his associates. The sensitivities of the capped... (Source: Skin and Allergy News) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Psoriatic arthritis associated with heavy drinking (Fri, 17 Apr 2015)
Heavy alcohol consumption was associated with incident psoriatic arthritis in women, Shaowei Wu, Ph.D., and his associates reported in a study of 116,430 female registered nurses in the Nurses’ Health Study II. The investigators found 141 incident cases of psoriatic arthritis (PsA) during... (Source: Skin and Allergy News)
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Evaluation of performance of BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in a Brazilian cohort of 1492 patients with spondyloarthritis: data from the Brazilian Registry of Spondyloarthritides (RBE) (Fri, 17 Apr 2015)
Conclusion In this heterogeneous Brazilian series of SpA patients, BASDAI was able to demonstrate “disease activity” in patients with axial as well as peripheral disease. (Source: Revista Brasileira de Reumatologia)
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Use of off-label doses is frequent in biologic therapy for moderate to severe psoriasis: A cross-sectional study in clinical practice (Fri, 17 Apr 2015)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
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Clinical symptoms and self-reported disease severity among patients with psoriasis – Implications for psoriasis management (Fri, 17 Apr 2015)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment)
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Evidence-based adverse effects of biologic agents in the treatment of moderate-to-severe psoriasis: Providing clarity to an opaque topic (Fri, 17 Apr 2015)
Journal of Dermatological Treatment, Ahead of Print. (Source: Journal of Dermatological Treatment) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Obesity and the metabolic syndrome in pediatric psoriasis (Fri, 17 Apr 2015)
Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, the metabolic syndrome, and associated comorbidities, including insulin resistance/type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease. This association is postulated to arise, at least in part, as a result of a systemic proinflammatory state that is mediated by adipose tissue. Several recent observational studies suggest that children and adolescents with psoriasis may be at increased risk of being overweight and obese as well as having an increased risk for features of the metabolic syndrome. (Source: Clinics in Dermatology)
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New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2 -deficient mice (Fri, 17 Apr 2015)
Abstract Chronic non-bacterial osteomyelitis (CNO), chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome are autoinflammatory disorder(s) in which sterile osteomyelitis is frequently accompanied by inflammatory conditions of the joints, skin, or intestine. Patients with CRMO commonly have a personal or family history of psoriasis, inflammatory bowel disease, and inflammatory arthritis, suggesting shared disease pathogenesis. Work by our group and others has demonstrated that dysregulation of interleukin-1 (IL-1) signaling can drive sterile osteomyelitis in the two human monogenic forms of the disease. Recent work in the chronic multifocal osteomyelitis (cmo) mouse model demonstrates that the disease is IL-1-m...
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Biologics for Psoriasis: A Translational Research Success Story (Fri, 17 Apr 2015)
Journal of Investigative Dermatology 135, 1205 (May 2015). doi:10.1038/jid.2014.549 Author: Mark Lebwohl (Source: Journal of Investigative Dermatology)
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Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures (Fri, 17 Apr 2015)
Authors: Manja Koch, Hansjörg Baurecht, Janina S Ried, Elke Rodriguez, Sabrina Schlesinger, Natalie Volks, Christian Gieger, Ina-Maria Rückert, Luise Heinrich, Christina Willenborg, Catherine Smith, Annette Peters, Barbara Thorand, Wolfgang Koenig, Claudia Lamina, Henning Jansen, Florian Kronenberg, Jochen Seissler, Joachim Thiery, Wolfgang Rathmann, Heribert Schunkert, Jeanette Erdmann, Jonathan Barker, Rajan P Nair, Lam C Tsoi, James T Elder, Ulrich Mrowietz, Michael Weichenthal, Sören Mucha, Stefan Schreiber, Andre Franke, Jochen Schmitt, Wolfgang Lieb & Stephan Weidinger (Source: Journal of Investigative Dermatology)
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