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MedWorm: Psoriasis

Effect of Narrow-Band Ultraviolet B Phototherapy and Methotrexate on MicroRNA (146a) Levels in Blood of Psoriatic Patients. (Fri, 27 Nov 2015)
Conclusion. The expression of miRNA146a is increased in whole blood samples from psoriasis patients, so we can evaluate its possibility to work as a future therapeutic objective in the treatment of psoriasis. With these markers, it is able to screen therapeutics effect or changes to a further aggressive treatment for psoriasis. PMID: 26604920 [PubMed - as supplied by publisher] (Source: Dermatology Research and Practice) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Rates of Cardiovascular Disease and Major Adverse Cardiovascular Events in Patients With Psoriatic Arthritis Compared to Patients Without Psoriatic Arthritis (Thu, 26 Nov 2015)
Conclusions: The rates of CVD and MACE were slightly higher in the patients with PsA compared to the patients without PsA. Among the patients with PsA, rates of both outcomes were higher among those who received prescriptions for systemic PsA treatments. (Source: JCR: Journal of Clinical Rheumatology)
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Bone remodeling in psoriasis and psoriatic arthritis: an update (Thu, 26 Nov 2015)
This article reviews and outlines recent advances in the field of bone remodeling in psoriatic disease and identify avenues for further research. Recent findings: High-resolution imaging revealed that new bone formation, observed in psoriatic arthritis (PsA) is centered at enthesial sites in contrast to hand osteoarthritis, and new bone formation is also present in psoriasis patients without arthritis. Accumulating evidence strongly suggests that the IL-23/IL-17 pathway is directly involved in altered bone phenotypes in PsA. Apart from Th17 and Th22 cells, CD8+IL-17+ T cells, γδT cells, and type 3 innate lymphoid cells also secrete IL-17 and IL-22. Further studies will be needed to clarify the role of these cells in bone remodeling in the context of psoriatic disease. Recent research als...
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Clinical manifestations in uveitis patients with and without rheumatic disease in the Chinese population in Taiwan (Thu, 26 Nov 2015)
Conclusion The disease course and clinical manifestations of rheumatic disease-related uveitis were different from those unrelated. Patients with rheumatic disease-related uveitis had a higher recurrent rate and the more frequent posterior synechiae than patients without rheumatic diseases. (Source: Journal of Microbiology, Immunology and Infection)
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Small molecules with anti-inflammatory properties in clinical development (Thu, 26 Nov 2015)
Publication date: Available online 26 November 2015 Source:Pharmacology & Therapeutics Author(s): Thomas Hanke, Daniel Merk, Dieter Steinhilber, Gerd Geisslinger, Manfred Schubert-Zsilavecz Inflammation is a crucial physiological response of our body to any kind of noxa be it an infection or tissue injury. However, this physiological process can be detrimental if dysregulated and, when the acute inflammatory response fails to resolve the cause of inflammation, there can be a switch to chronification. According to ICD 10 (WHO) over 3.000 diseases exist with the suffix “–itis” which terms an inflammatory disease. For the treatment of inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) are the most widespread drugs while glucocorticoids are amongst our strongest ...
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Implications of Rheumatic Disease and Biological Response-Modifying Agents in Plastic Surgery (Wed, 25 Nov 2015)
Summary: The preoperative evaluation for any reconstructive or aesthetic procedure requires a detailed history of existing medical conditions and current home medications. The prevalence of rheumatic diseases such as rheumatoid arthritis, gout, and psoriasis is high, but the impact of these chronic illnesses on surgical outcome and the side effects of the powerful medications used for treatment are often underappreciated. In this review, the authors highlight key perioperative considerations specific to rheumatologic diseases and their associated pharmacologic therapies. In particular, the authors discuss the perioperative management of biological response-modifying agents, which have largely become the new standard of therapy for many rheumatic diseases. The literature reveals three key p... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration (Wed, 25 Nov 2015)
Abstract Psoriasis is considered as a model for chronic immune-mediated disorders. Th17-cells are pivotal players in those diseases. Recently, we demonstrated that Th17-cells produce interleukin (IL)-29 and that IL-29 is highly present in psoriatic lesions. Whether IL-29, with its action on epithelial cells and melanocytes, contributes to psoriasis pathogenesis, was unknown so far. Analysis of IL-29-treated human keratinocytes revealed induction of the chemokines CXCL10, CXCL11, and, to a much lesser extent, CXCL9. Unlike these CXCR3A ligands, known to attract Th1-, CD8+, NK-, and Th1/Th17 transient cells, no influence was found on chemokines attracting other immune cell populations or on molecules modulating the CXCR3A/CXCR3A ligand interaction. CXCR3A ligand expression was also...
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Beyond Psoriasis: Novel Uses for Biologic Response Modifiers in Pediatric Dermatology (Wed, 25 Nov 2015)
Abstract Dermatologists have witnessed the increasing availability of novel biologic response modifiers for the treatment of inflammatory and autoimmune diseases in recent years. The most common dermatologic indication for the use of biologic response modifiers in adults is psoriasis, but the U.S. Food and Drug Administration has not approved any of these agents for use in any dermatologic disease in children with the exception of omalizumab, and as such, use in this population is considered off‐label. In this review, we focus on the use of these agents in children to treat inflammatory skin diseases other than psoriasis, including atopic dermatitis, hidradenitis suppurativa, pemphigus vulgaris, bullous pemphigoid, and toxic epidermal necrolysis, with an emphasis on the use of etanercept...
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Psoriasis and Migraine: What's the Connection?Psoriasis and Migraine: What's the Connection? (Wed, 25 Nov 2015)
A disease severity-dependent increased risk for migraine in psoriasis and increased risk for new-onset migraine in psoriatic arthritis could be mediated by the usual suspects--proinflammatory cytokines. Medscape Dermatology (Source: Medscape Allergy Headlines)
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Landmark clinical trial of a novel combination treatment for type 1 diabetes (Tue, 24 Nov 2015)
(McGill University) Investigators at Montreal's Lady Davis Institute at the Jewish General Hospital and McGill University Health Centre have announced the start of a landmark clinical study aimed at restoring normal insulin secretion in people with longstanding type 1 diabetes. The treatment combines INGAP Peptide (ExsulinTM), which stimulates growth of the insulin secreting islets, and ustekinumab (SteleraTM), a drug approved for the treatment of psoriasis. (Source: EurekAlert! - Medicine and Health)
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