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MedWorm: Psoriasis

Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trondelag health study (HUNT) (Tue, 01 Apr 2014)
Conclusion: A history of previous CV disease was associated with increased risk of incident RA but not osteoarthritis. (Source: Arthritis Research and Therapy) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Assessment of safety profile of Stelara® for moderate to severe psoriasis (Tue, 01 Apr 2014)
New clinical data from PSOLAR, an international disease-based registry, provide real-world outcomes regarding the use of psoriasis treatments by dermatologists in clinical practice. The data was presented at the 72nd Annual Meeting of the American Academy of Dermatology (AAD) in Denver, Colorado, USA. (Source: Pharmacy Europe)
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A measure of chronic quality of life predicts socioeconomic and medical outcomes in psoriasis patients (Mon, 31 Mar 2014)
ConclusionCompared to the standard LW DLQI, LT DLQI was a better predictor of patient outcomes related to weight, discrimination and depression. (Source: Journal of the European Academy of Dermatology and Venereology)
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Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis (Mon, 31 Mar 2014)
Conclusion: IL-23 inhibition with a single dose of guselkumab results in clinical responses in patients with moderate-to-severe psoriasis, suggesting that neutralization of IL-23 alone is a promising therapy for psoriasis. (Source: Journal of Allergy and Clinical Immunology)
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Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5‐year observational study of clinical practice: 2008–2013 results of the Biobadaderm registry (Sun, 30 Mar 2014)
ConclusionPatients receiving biologics had lower risk of AE. We did not find differences in the risk of serious or fatal AE. (Source: Journal of the European Academy of Dermatology and Venereology)
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Treatment adherence: a hurdle for real‐life effectiveness in psoriasis? (Sun, 30 Mar 2014)
(Source: Journal of the European Academy of Dermatology and Venereology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Non‐adherence and measures to improve adherence in the topical treatment of psoriasis (Sun, 30 Mar 2014)
This article proposes that given that the barriers to medication adherence are complex and varied, solutions to improve adherence and thus clinical outcomes must be multifaceted and must also provide the possibility to be tailored according to each patient's individual needs. Such an individualized and comprehensive adherence‐enhancing intervention would probably enable the successful long‐term management of this disabling chronic condition. (Source: Journal of the European Academy of Dermatology and Venereology)
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Pooled safety analysis of calcipotriol plus betamethasone dipropionate gel for the treatment of psoriasis on the body and scalp (Sun, 30 Mar 2014)

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Expert recommendations: the use of the fixed combination calcipotriol and betamethasone dipropionate gel for the topical treatment of psoriasis (Sun, 30 Mar 2014)
Abstract Treatment non‐adherence is a general challenge and a complex problem. It is a key factor that impacts the ‘real‐life’ effectiveness of topical treatments for chronic disorders, such as psoriasis. Here, we provide our expert opinion on the real‐life effectiveness of topical psoriasis treatment, using the fixed combination gel (Daivobet® gel; calcipotriol plus betamethasone dipropionate) as a case study. The fixed combination gel is a first‐line topical treatment for mild‐to‐moderate psoriasis, developed to be the gold‐standard therapy for psoriasis patients. This fixed combination gel is an effective and well‐tolerated topical psoriasis treatment that the majority of our patients prefer to the ointment formulation. We assessed our real‐life experience and con...
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T cell immune responses in psoriasis. (Sat, 29 Mar 2014)
Authors: Jadali Z, Eslami MB Abstract A central role for T cells and their cytokines in the pathogenesis of psoriasis has been proposed; however, there are controversies over the details of this issue. The goal of this study is to summarise currently available data on the importance of T cells in psoriasis pathogenesis.A systematic review of the English medical literature was conducted by searching PubMed, Embase, ISI Web of Knowledge, and Iranian databases including Iranmedex, and SID for studies on associations between the involvement of T cell subsets and psoriasis.The results of the present study indicate that alterations in the number and function of different subsets of T-cells are associated with psoriasis.It appears that studies on T cell subsets contributed to understandin...
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