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MedWorm: Psoriasis

Regulation of Dendritic Cell Function in Inflammation. (Sun, 02 Aug 2015)
Authors: Said A, Weindl G Abstract Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermati... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Pemphigoid Diseases as a Sign of Active Psoriasis: A Case Report and Brief Review (Sat, 01 Aug 2015)
Conclusion: BP can be a sign of active psoriasis in the present case.Dermatology (Source: Dermatology)
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The value of a multi-specialty service, including genitourinary medicine, dermatology and urology input, in the management of male genital dermatoses (Fri, 31 Jul 2015)
We undertook a retrospective case note review of our monthly multi-specialty penile dermatoses clinic (which includes clinicians from Genitourinary medicine, Dermatology and Urology), to examine conditions presenting to the service, and compare clinical management and outcomes with other similar services in the UK. Over the 3-year study period, 226 patients were reviewed over 240 individual episodes. Lichenoid conditions were the most common category of genital pathologies seen (n = 60, 24%), but non-specific balanitis was the most common individual diagnosis (n = 55, 22%). Other common conditions seen included eczema and psoriasis (n = 28, 11%), Zoon/plasma cell balanitis (n = 26, 10%), malignancy/pre-malignant change (n = 25, 10%) and infective conditions (n = 24, 9%). The clinic had a b...
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Your Psoriasis Questions Answered (Fri, 31 Jul 2015)
Recently, a couple of leading skin experts took questions from WebMD's Psoriasis Community. Here are highlights from the online chat with Colby Evans, MD, and Mary Ruth Buchness, MD. (Source: WebMD Health)
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Paradoxical psoriasis in a large cohort of patients with inflammatory bowel disease receiving treatment with anti‐TNF alpha: 5‐year follow‐up study (Fri, 31 Jul 2015)
ConclusionsParadoxical psoriasis is a relevant side effect of anti‐TNF alpha therapy, with an incidence rate of five per 100 person‐years. Smoking is confirmed as the main risk factor for developing lesions. The combination therapy with anti‐TNF alpha plus immunosuppressants is associated with a reduced risk of paradoxical psoriasis. (Source: Alimentary Pharmacology and Therapeutics)
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Progressive neurologic dysfunction in a psoriasis patient treated with dimethyl fumarate (Thu, 30 Jul 2015)
We report a psoriasis patient who presented with progressive neurologic dysfunction and seizures after 2.5 years of fumarate therapy. Despite absolute lymphocyte counts remaining between 500‐1000/mm3, his CD4+ and CD8+ T‐cell counts were markedly low. MRI showed right hemispheric and brainstem lesions and JC virus DNA was undetectable in his cerebrospinal fluid. Brain biopsy revealed typical features of PML as well as JC virus‐infected neurons. Clinicians should consider PML in the differential diagnosis of fumarate‐treated patients presenting with brain lesions or seizures even in the absence of severe lymphocytopenia. ANN NEUROL 2015 (Source: Annals of Neurology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Total cholesterol, lipoprotein, and triglyceride levels in tumor necrosis factor inhibitor‐treated patients with psoriasis, psoriatic arthritis, or rheumatoid arthritis (Thu, 30 Jul 2015)
(Source: International Journal of Dermatology)
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Skin Plaques Mimicking Psoriasis (Thu, 30 Jul 2015)
A 4-year-old girl with a medical history of Trisomy 21 presented with a diffuse, pruritic, scaly rash affecting her entire body. The rash began on her scalp as small areas of scaling and crusting then spread to her hands and feet. She had multiple visits to the emergency department with each exacerbation of rash and had been prescribed medications that included ketoconazole, permethrin, and triamcinolone. She was also evaluated previously by a dermatologist and was diagnosed with psoriasis. Of the 9 relatives with whom she had lived, each had received intermittent treatment for scabies over a period of 3 years. (Source: The Journal of Pediatrics)
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Patients With Psoriasis Should be Examined for Uveitis Patients With Psoriasis Should be Examined for Uveitis (Thu, 30 Jul 2015)
A study performed in a largely white population in Denmark identified a bidirectional association between psoriasis and uveitis. Medscape Medical News (Source: Medscape Medical News Headlines)
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Tattoo‐induced psoriasis (Wed, 29 Jul 2015)
(Source: International Journal of Dermatology)
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