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MedWorm: Psoriasis

Safety Observations in 12095 Patients With Psoriasis Enrolled in an International Registry (PSOLAR): Experience With Infliximab and Other Systemic and Biologic Therapies. (Sat, 24 Jan 2015)
CONCLUSIONS: Based on PSOLAR data through 2013, no new safety concerns were observed with infliximab for all-cause mortality, MACE, or malignancy; the data suggest that infliximab was associated with serious infections.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(12):1441-1448. PMID: 25607786 [PubMed - in process] (Source: Journal of Drugs in Dermatology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Efficacy of botulinum neurotoxin type a for treating recalcitrant plaque psoriasis. (Sat, 24 Jan 2015)
We describe sustained local clearance of a psoriasis plaque in a patient following a single off-label injection of intradermal abobotulinumtoxinA. BoNTA may offer a novel therapeutic approach for treating recalcitrant plaque psoriasis.<br /> Case reports and anecdotal evidence suggests that onabotulinumtoxinA may be useful for treating inverse psoriasis.1,2 We previously reported an improvement in skin phenotype in a preclinical mouse model following a single intradermal injection of abobotulinumtoxinA.3 Here we present a patient case report demonstrating efficacy of abobotulinumtoxinA in reversing plaque psoriasis.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1407-1408. PMID: 25607710 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Real-life treatment profile of calcipotriene and betamethasone dipropionate topical suspension in patients with psoriasis vulgaris. (Sat, 24 Jan 2015)
CONCLUSION: The results of this noninterventional study are consistent with previously reported data from interventional trials and suggest that treatment with CBD topical suspension is efficacious and well tolerated and improves quality of life in patients with psoriasis vulgaris.<BR /><BR /> <EM>J Drugs Dermatol.</EM> 2014;13(11):1374-1379. PMID: 25607705 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Assessment of cardiovascular risk in patients with moderate to severe plaque psoriasis. (Sat, 24 Jan 2015)
CONCLUSIONS: Cardiovascular risk was greater in patients with moderate to severe psoriasis than in patients with other dermatological conditions, suggesting that early detection and tailored management of risk factors is essential to reducing cardiovascular morbidity in these patients.<BR /><BR /> <EM>J Drugs Dermatol</EM>. 2014;13(10):1240-1247. PMID: 25607559 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
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Calcitriol exerts anti‐inflammatory effects in keratinocytes treated with autoantibodies from a patient with bullous pemphigoid (Sat, 24 Jan 2015)
ConclusionAlthough the results of this study are based on autoantibodies prepared from a single patient, they show that calcitriol protects from BP IgG‐induced inflammatory processes in vitro, thus favouring its potential inclusion into the therapeutic repertoire of BP. (Source: Journal of the European Academy of Dermatology and Venereology)
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Prodifferentiation, Anti-Inflammatory and Antiproliferative Effects of Delphinidin, a Dietary Anthocyanidin, in a Full-Thickness Three-Dimensional Reconstituted Human Skin Model of Psoriasis (Sat, 24 Jan 2015)
Conclusions: These observations provide a rationale for developing delphinidin for the management of psoriasis.Skin Pharmacol Physiol 2015;28:177-188 (Source: Skin Pharmacology and Physiology) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Psoriasis Vulgaris with or without Arthritis and Independent of Disease Severity or Duration Is a Risk Factor for Hypercholesterolemia (Sat, 24 Jan 2015)
Conclusion: Based on our population Ps is associated with alterations in TCh and LDL cholesterol, but not in TGs and HDL cholesterol, when ATP III panel levels are used. These alterations are not related to disease duration.Dermatology (Source: Dermatology)
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FDA Clears Secukinumab (Cosentyx) for Plaque PsoriasisFDA Clears Secukinumab (Cosentyx) for Plaque Psoriasis (Fri, 23 Jan 2015)
Secukinumab is indicated for treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy. FDA Approvals (Source: Medscape Allergy Headlines)
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FDA Approves New Psoriasis Drug Cosentyx (Fri, 23 Jan 2015)
Source: Food and Drug Administration Related MedlinePlus Page: Psoriasis (Source: MedlinePlus Health News)
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Role of skin biopsy in papulosquamous lesions—a comparative study (Fri, 23 Jan 2015)
This study was done to assess the correlation between the clinical diagnoses of papulosquamous lesions made at dermatological clinics and the diagnosis of these lesions at biopsy. Our study lends insight into the list of most common to least common lesions of papulosquamous lesions. This is a cross-sectional study conducted at a dermatological clinic, on those patients who consulted to a dermatologist. This presumptive investigation on papulosquamous lesion was implied on 83 patients as lichen planus, lichen nitidus, lichen striata, lichenoides dermatitis, psoriasis, pityriasis rubra pilaris, pityriasis rosea, pityriasis lichenoides, pityriasis lichenoides et varioliformis acuta (PLEVA) and Reiter’s disease and then the biopsy was performed on these patients for the confirmation of the c...
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