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MedWorm: Psoriasis

Regulated genes in psoriatic skin during treatment with fumaric acid esters (Tue, 30 Sep 2014)
ConclusionsFAE treatment induces glutathione and Nrf2 pathway genes in lesional skin of patients with psoriasis. In responders, FAEs specifically regulate the transcription factors PTTG1, NR3C1, GATA3 and NFκBIZ, which are important in normal cutaneous development, and the T‐helper (Th)2 and Th17 pathways, respectively. (Source: British Journal of Dermatology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Downregulation of involucrin in psoriatic lesions following therapy with propylthiouracil, an anti‐thyroid thioureylene: immunohistochemistry and gene expression analysis (Tue, 30 Sep 2014)
ConclusionsIn psoriasis, there is increased expression of involucrin, which leads to abnormal keratinocyte differentiation and hence to the formation of psoriatic plaques. The therapeutic effect of PTU in psoriasis may be attributable to the downregulation of involucrin. Larger trials should further elucidate the mechanism and therapeutic potential of PTU in psoriasis. (Source: International Journal of Dermatology)
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Quality of life and related factors in a cohort of plaque‐type psoriasis patients in La Coruña, Spain (Tue, 30 Sep 2014)
ConclusionsFactors associated with greater impairment of QoL were gender, psoriasis duration, and type of treatment. Patients receiving systemic and biologic therapies reported better QoL. (Source: International Journal of Dermatology)
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Are patients with mild to moderate psoriasis more physically active than healthy controls? Comments on the study by Demirel et al. (Tue, 30 Sep 2014)
(Source: International Journal of Dermatology)
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Membrane and soluble Toll‐like receptor 2 in patients with psoriasis treated by Goeckerman therapy (Tue, 30 Sep 2014)
ConclusionsMembrane and soluble TLR2 may be involved in the pathogenesis of psoriasis. Both remained unchanged by GT. (Source: International Journal of Dermatology)
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Evaluation of body composition parameters in patients with psoriasis (Tue, 30 Sep 2014)
ConclusionsThe present study provides evidence of a relationship between some body composition parameters and the occurrence of psoriasis. We suggest that body composition parameters should be analyzed not only in obese psoriasis patients but in all psoriasis patients upon their first diagnosis. Systemic therapy does not appear to cause any changes in body composition parameters. (Source: International Journal of Dermatology) MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.
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Distribution Pattern of Psoriasis Affects Sexual Function in Moderate to Severe Psoriasis: A Prospective Case Series Study (Mon, 29 Sep 2014)
ConclusionsThis is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when deciding on treatment for psoriasis patients. Molina‐Leyva A, Almodovar‐Real A, Ruiz‐Carrascosa JC, Naranjo‐Sintes R, Serrano‐Ortega S, and Jimenez‐Moleon JJ. Distribution pattern of psoriasis affects sexual function in moderate to severe psoriasis: A prospective case series study. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)
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Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population (Sat, 27 Sep 2014)
Summary Psoriasis is a chronic inflammatory skin disease occurred under the interaction of genetic and environmental factors. The genes HLA complex P5 (HCP5), spermatogenesis associated 2 (SPATA2), tumour necrosis factor alpha‐induced protein 3 (TNFAIP3), TNFAIP3‐interacting protein 1 (TNIP1) and the component of oligomeric Golgi complex 6 (COG6) were reported to be associated with psoriasis in western populations by genome‐wide association studies. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. One single nucleotide polymorphism (SNP) from each gene was evaluated using Chinese patients with psoriasis (n = 201) and controls (n = 300). The results demonstrated that SNPs...
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The role of human 6‐sulfo LacNAc dendritic cells (slanDCs) in autoimmunity and tumor diseases (Sat, 27 Sep 2014)
Summary Dendritic cells play a central role in the regulation of immunological reactivity. The existence of functionally specialized populations of dendritic cells in the skin is a consequence of qualitatively different attacks on our organism. slanDCs are human inflammatory dendritic cells that are characterized by the specific expression of the carbohydrate 6‐sulfo LacNAc (slan). After phenotypic maturation, slanDCs are capable of producing very high amounts of proinflammatory mediators such as IL‐12, TNF‐α, IL‐1β and IL‐23. Recent data describe a potential role of slanDCs in a number of different diseases like psoriasis, lupus erythematosus, and tumors, thus opening up new areas of research on their respective pathogenesis. Furthermore, a slanDC‐specific targeting system h...
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Die Bedeutung von humanen 6‐sulfo LacNAc dendritischen Zellen (slanDCs) bei Autoimmunität und Tumorerkrankungen (Sat, 27 Sep 2014)
Zusammenfassung Dendritische Zellen spielen eine wichtige Rolle bei der Regulation immunologischer Reaktivität. Die Existenz funktionell spezialisierter Populationen dendritischer Zellen der Haut ist eine Konsequenz der unterschiedlichen Qualität von Angriffen auf unseren Organismus. Als slanDCs werden inflammatorische dendritische Zellen des Menschen bezeichnet, die sich durch die spezifische Expression des Zuckers 6‐sulfo LacNAc (slan) auszeichnen. Nach phänotypischer Maturation besitzen slanDCs die Fähigkeit zur Produktion großer Mengen proinflammatorischer Mediatoren wie IL‐12, TNF‐α, IL‐1β und IL‐23. Aktuelle Daten beschreiben eine mögliche Bedeutung dieser proinflammatorischen Zellen bei so unterschiedlichen Erkrankungen wie der Psoriasis, dem Lupus erythematodes ab...
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