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MedWorm: Psoriasis

Severe erytrodermic psoriasis in child twins: from clinical-pathological diagnosis to treatment of choice through genetic analyses: two case reports (Wed, 17 Dec 2014)
Conclusion: Pediatric erythroderma may pose a great challenge as a potentially life-threatening condition causing extreme distress in children, parents and pediatricians. In young patients it is mandatory to establish correct clinical and instrumental procedures, possibly supplemented by genetic analyses such as those we required, in order to determine an effective and safe therapy in terms of cost-benefit and put patients and family in the best condition to perform common daily activities. (Source: BMC Research Notes) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Psoriatic arthritis: current therapy and future approaches (Wed, 17 Dec 2014)
PsA is a systemic inflammatory condition that affects 20–30% of patients with psoriasis. It is characterized by potential involvement of diverse tissues, including peripheral and axial joints, enthesitis, dactylitis and skin and nail disease. The degree of involvement in each domain can vary over time in individual patients and can differ substantially between PsA patients. The clinical heterogeneity along with the varying extent of severity and activity can pose significant challenges to treatment. Although some studies had suggested immunopathophysiological similarities between PsA and RA, more recently important distinctions have been defined. Similarly, although some immunomodulatory therapies have proved effective for both PsA and RA, recent data suggest distinct responses to ce...
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Childhood-onset PsA in Down syndrome with psoriasis susceptibility variant CARD14 rs11652075 (Wed, 17 Dec 2014)
(Source: Rheumatology)
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The Worst Itch Numeric Rating Scale for patients with moderate to severe plaque psoriasis or psoriatic arthritis (Tue, 16 Dec 2014)
Abstract Plaque psoriasis (PP) and psoriatic arthritis (PsA) are autoinflammatory chronic conditions associated with skin involvement. Pruritus, or itching, is a prevalent and bothersome symptom in patients with PP and is associated with reduced health‐related quality of life. The Worst Itch Numeric Rating Scale (WI‐NRS) has been developed as a simple, single item with which to assess the patient‐reported severity of this symptom at its most intense during the previous 24‐hour period. Qualitative research was undertaken to assess the content validity of the WI‐NRS. Patients with moderate to severe PP and patients with PsA were recruited from clinical sites in the USA. The qualitative research entailed two‐part interviews, which began with concept elicitation to gain understandi...
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Comorbidity profiles in association with vitiligo: a nationwide population‐based study in Taiwan (Tue, 16 Dec 2014)
ConclusionOur study not only confirmed the significant association of vitiligo with multiple autoimmune and atopic diseases in Taiwan but also disclosed several unique findings, including the much lower prevalence of vitiligo, delayed onset of vitiligo by three decades, different associated comorbidity profiles comparing to westerners and the age‐ and gender‐specific approach for the vitiligo‐associated comorbidities. (Source: Journal of the European Academy of Dermatology and Venereology)
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Finger and toenail onycholysis (Tue, 16 Dec 2014)
Abstract Onycholysis – the separation of the nail plate from the nail bed occurs in fingers and toenails. It is diagnosed by the whitish appearance of the separated nail plate from the nail bed. In fingers, the majority is caused by trauma, manicuring, occupational or self‐induced behavior. The most common disease producing fingernail onycholysis is psoriasis and pustular psoriasis. Phototoxic dermatitis, due to drugs can also produce finger onycholysis. Once the separation occurs, the environmental flora sets up temporary colonization in the available space. Finger onycholysis is most common in women. Candida albicans is often recovered from the onycholytic space. Many reports, want to associate the yeast as cause and effect, but the data are lacking and the treatment of the candida d... MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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Novartis' Phase IIIb CLEAR trial of psoriasis drug Cosentyx meets endpoints (Tue, 16 Dec 2014)
Swiss drug-maker Novartis has reported positive results from its Phase IIIb CLEAR trial of Cosentyx (secukinumab, formerly known as AIN457) in patients with psoriasis. (Source: Drug Development Technology)
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Is This The Future Of Late-Stage Drug Development? (Mon, 15 Dec 2014)
On Friday, Novartis announced that its anti-IL17A antibody secukinumab (Cosentyx™) demonstrated clear superiority over its rival, Stelara™ ustekinumab from Johnson & Johnson, an antibody against IL-12 and IL-23, in the treatment of psoriasis. (Source: Forbes.com Healthcare News)
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Is donkey milk the next big thing? (Mon, 15 Dec 2014)
Cleopatra bathed every day in asses' milk, and Pope Francis said he thrived on it as a baby. Now remarkable results are being reported in people with asthma, eczema and psoriasis who drink it or use soap made from it. (Source: Telegraph Health)
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Novartis Psoriasis Drug Tops J and J's StelaraNovartis Psoriasis Drug Tops J and J's Stelara (Mon, 15 Dec 2014)
Novartis said on Friday its experimental psoriasis drug Cosentyx (secukinumab) was better at clearing the rough skin patches associated with the disease than Johnson & Johnson's Stelara (ustekinumab). Reuters Health Information (Source: Medscape Medical News Headlines) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too.
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